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Smoking and early COPD as independent predictors of body composition, exercise capacity, and health status

dc.contributor.authorCaram, Laura Miranda De Oliveira [UNESP]
dc.contributor.authorFerrari, Renata [UNESP]
dc.contributor.authorBertani, Andr� Lu�s [UNESP]
dc.contributor.authorGarcia, Tha�s [UNESP]
dc.contributor.authorMesquita, Carolina Bonfanti [UNESP]
dc.contributor.authorKnaut, Caroline [UNESP]
dc.contributor.authorTanni, Suzana Erico [UNESP]
dc.contributor.authorGodoy, Irma [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:06:49Z
dc.date.available2018-12-11T17:06:49Z
dc.date.issued2016-10-01
dc.description.abstractThe effects of tobacco smoke, mild/moderate COPD disease and their combined effect on health status (HS), body composition (BC), and exercise capacity (EC) impairment are still unclear. We hypothesized that smoking and early COPD have a joint negative influence on these outcomes. We evaluated 32 smokers (smoking history >10 pack/years), 32 mild/moderate COPD (current smokers or former smokers), and 32 never smokers. All individuals underwent medical and smoking status evaluations, pre and post-bronchodilator spirometry, BC [fat-free mass (FFM) and FFM index (FFMI)], EC [six-minute walk distance (6MWD)] and HS [Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36)]. FFM (p = 0.02) and FFMI (p = 0.008) were lower in COPD than never smokers. 6MWT, as a percentage of reference values for the Brazilian population, was lower in COPD and smokers than never smokers (p = 0.01). Smokers showed worse SF-36 score for functional capacity than never smokers (p<0.001). SF-36 score for physical functioning (p<0.001) and role-emotional (p<0.001) were impaired in COPD patients than smokers. SF-36 scores for physical functioning (p<0.001), role-physical (p = 0.01), bodily pain (p = 0.01), vitality (p = 0.04) and role-emotional (p<0.001) were lower in COPD than never smokers. Multiple linear regression analysis showed that both COPD diagnosis and smoking were inversely associated with FFMI, 6MWD and HS. Smoking and early COPD have a joint negative influence on body composition, exercise capacity and health status.en
dc.description.affiliationDepartment of Internal Medicine Pneumology Area Botucatu Medical School UNESP - Univ Estadual Paulista
dc.description.affiliationUnespDepartment of Internal Medicine Pneumology Area Botucatu Medical School UNESP - Univ Estadual Paulista
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0164290
dc.identifier.citationPLoS ONE, v. 11, n. 10, 2016.
dc.identifier.doi10.1371/journal.pone.0164290
dc.identifier.file2-s2.0-84991288252.pdf
dc.identifier.issn1932-6203
dc.identifier.scopus2-s2.0-84991288252
dc.identifier.urihttp://hdl.handle.net/11449/173614
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleSmoking and early COPD as independent predictors of body composition, exercise capacity, and health statusen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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