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Prevalence study of SNP c.421G>T in the ADAMTS2 gene responsible for dermatosparaxis in White Dorper sheep in Brazil

dc.contributor.authorAndrade, Danilo G.A. [UNESP]
dc.contributor.authorDalanezi, Felipe M. [UNESP]
dc.contributor.authorTrecenti, Anelize S. [UNESP]
dc.contributor.authorCunha, Paulo Henrique J.
dc.contributor.authorBorges, Alexandre S. [UNESP]
dc.contributor.authorOliveira-Filho, José P. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2018-12-11T16:42:00Z
dc.date.available2018-12-11T16:42:00Z
dc.date.issued2016-02-01
dc.description.abstractDermatosparaxis is an autosomal recessive disorder of connective tissue; the disorder is clinically characterized by skin fragility and hyperextensibility. Dermatosparaxis in White Dorper sheep is caused by a single nucleotide polymorphism (SNP) (c.421G>T) in the ADAM metalloproteinase with thrombospondin type 1 motif, 2 (ADAMTS2) gene. The aim of this study was to investigate the prevalence of this SNP in a White Dorper herd in São Paulo state, Brazil. In this study, we collected blood DNA samples from 303 White Dorper sheep and performed polymerase chain reaction to amplify the SNP region. The samples were sequenced to determine the presence of the SNP in the ADAMTS2 gene. The SNP prevalence in the studied population was 15.5%; this finding indicates that more effective control measures should be used to prevent the inheritance of SNP c.421G>T in the ADAMTS2 gene in Brazilian White Dorper herds.en
dc.description.affiliationDepartamento de Clínicas Veterinárias Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (Unesp), Campus de Botucatu, Distrito de Rubiao Junior s/n
dc.description.affiliationDepartamento de Medicina Veterinária Escola de Veterinária Universidade Federal de Goiás (UFG), Campus Samambaia (Campus II), Cx. Postal 131
dc.description.affiliationUnespDepartamento de Clínicas Veterinárias Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (Unesp), Campus de Botucatu, Distrito de Rubiao Junior s/n
dc.format.extent73-76
dc.identifierhttp://dx.doi.org/10.1590/S0100-736X2016000200002
dc.identifier.citationPesquisa Veterinaria Brasileira, v. 36, n. 2, p. 73-76, 2016.
dc.identifier.doi10.1590/S0100-736X2016000200002
dc.identifier.fileS0100-736X2016000200073.pdf
dc.identifier.issn1678-5150
dc.identifier.issn0100-736X
dc.identifier.scieloS0100-736X2016000200073
dc.identifier.scopus2-s2.0-84963769368
dc.identifier.urihttp://hdl.handle.net/11449/168576
dc.language.isoeng
dc.relation.ispartofPesquisa Veterinaria Brasileira
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectAutosomal recessive
dc.subjectCutaneous asthenia
dc.subjectPCR
dc.subjectSheep
dc.subjectWhite dorper
dc.titlePrevalence study of SNP c.421G>T in the ADAMTS2 gene responsible for dermatosparaxis in White Dorper sheep in Brazilen
dc.typeArtigopt
dspace.entity.typePublication
unesp.author.lattes9643433706163946[5]
unesp.author.orcid0000-0001-6256-8089[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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