Prevalence study of SNP c.421G>T in the ADAMTS2 gene responsible for dermatosparaxis in White Dorper sheep in Brazil
dc.contributor.author | Andrade, Danilo G.A. [UNESP] | |
dc.contributor.author | Dalanezi, Felipe M. [UNESP] | |
dc.contributor.author | Trecenti, Anelize S. [UNESP] | |
dc.contributor.author | Cunha, Paulo Henrique J. | |
dc.contributor.author | Borges, Alexandre S. [UNESP] | |
dc.contributor.author | Oliveira-Filho, José P. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Federal de Goiás (UFG) | |
dc.date.accessioned | 2018-12-11T16:42:00Z | |
dc.date.available | 2018-12-11T16:42:00Z | |
dc.date.issued | 2016-02-01 | |
dc.description.abstract | Dermatosparaxis is an autosomal recessive disorder of connective tissue; the disorder is clinically characterized by skin fragility and hyperextensibility. Dermatosparaxis in White Dorper sheep is caused by a single nucleotide polymorphism (SNP) (c.421G>T) in the ADAM metalloproteinase with thrombospondin type 1 motif, 2 (ADAMTS2) gene. The aim of this study was to investigate the prevalence of this SNP in a White Dorper herd in São Paulo state, Brazil. In this study, we collected blood DNA samples from 303 White Dorper sheep and performed polymerase chain reaction to amplify the SNP region. The samples were sequenced to determine the presence of the SNP in the ADAMTS2 gene. The SNP prevalence in the studied population was 15.5%; this finding indicates that more effective control measures should be used to prevent the inheritance of SNP c.421G>T in the ADAMTS2 gene in Brazilian White Dorper herds. | en |
dc.description.affiliation | Departamento de Clínicas Veterinárias Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (Unesp), Campus de Botucatu, Distrito de Rubiao Junior s/n | |
dc.description.affiliation | Departamento de Medicina Veterinária Escola de Veterinária Universidade Federal de Goiás (UFG), Campus Samambaia (Campus II), Cx. Postal 131 | |
dc.description.affiliationUnesp | Departamento de Clínicas Veterinárias Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (Unesp), Campus de Botucatu, Distrito de Rubiao Junior s/n | |
dc.format.extent | 73-76 | |
dc.identifier | http://dx.doi.org/10.1590/S0100-736X2016000200002 | |
dc.identifier.citation | Pesquisa Veterinaria Brasileira, v. 36, n. 2, p. 73-76, 2016. | |
dc.identifier.doi | 10.1590/S0100-736X2016000200002 | |
dc.identifier.file | S0100-736X2016000200073.pdf | |
dc.identifier.issn | 1678-5150 | |
dc.identifier.issn | 0100-736X | |
dc.identifier.scielo | S0100-736X2016000200073 | |
dc.identifier.scopus | 2-s2.0-84963769368 | |
dc.identifier.uri | http://hdl.handle.net/11449/168576 | |
dc.language.iso | eng | |
dc.relation.ispartof | Pesquisa Veterinaria Brasileira | |
dc.rights.accessRights | Acesso aberto | pt |
dc.source | Scopus | |
dc.subject | Autosomal recessive | |
dc.subject | Cutaneous asthenia | |
dc.subject | PCR | |
dc.subject | Sheep | |
dc.subject | White dorper | |
dc.title | Prevalence study of SNP c.421G>T in the ADAMTS2 gene responsible for dermatosparaxis in White Dorper sheep in Brazil | en |
dc.type | Artigo | pt |
dspace.entity.type | Publication | |
unesp.author.lattes | 9643433706163946[5] | |
unesp.author.orcid | 0000-0001-6256-8089[5] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatu | pt |
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