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Loss of RKIP expression during the carcinogenic evolution of endometrial cancer

dc.contributor.authorMartinho, Olga
dc.contributor.authorFaloppa, Carlos Chaves
dc.contributor.authorNeto, Cristovam Scapulatempo
dc.contributor.authorLongatto-Filho, Adhemar [UNESP]
dc.contributor.authorBaiocchi, Glauco
dc.contributor.authorda Cunha, Isabela Werneck
dc.contributor.authorSoares, Fernando Augusto
dc.contributor.authorTavares Guerreiro Fregnani, Jose Humberto
dc.contributor.authorReis, Rui Manuel
dc.contributor.institutionBarretos Canc Hosp
dc.contributor.institutionUniv Minho
dc.contributor.institutionICVS 3Bs PT Govt Associate Lab
dc.contributor.institutionAC Camargo Hosp
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:39Z
dc.date.available2014-05-20T15:32:39Z
dc.date.issued2012-02-01
dc.description.abstractAims Endometrial cancer is one of the most common cancers in women worldwide, but there is a lack of diagnostic markers for early detection of these tumours. The raf kinase inhibitory protein (RKIP) negatively regulates the Raf/MEK/ERK pathway, and the downregulation of RKIP is associated with tumour progression and metastasis in several human neoplasms. The aim of this study was to assess the expression levels of RKIP in endometrial cancer and determine whether this expression correlates with clinical outcome in these patients.Methods Tissue microarrays constructed using tissue samples from 209 endometrial adenocarcinomas, 49 endometrial polyps and 48 endometrial hyperplasias were analysed for RKIP expression by immunohistochemistry.Results The authors found that RKIP expression decreases significantly during malignant progression of endometrial cancer; it is highly expressed in non-neoplastic tissues (polyps 79.6%; hyperplasias 87.5%) and expressed at very low levels in endometrioid adenocarcinomas (29.7%). No correlations were observed between RKIP expression, clinicopathological data and survival.Conclusion This study demonstrated for the first time that RKIP expression is lost during the carcinogenic evolution of endometrial tumours and that the loss of RKIP expression is associated with a malignant phenotype. Functional studies are needed to address the biological role of RKIP downregulation in endometrial cancer.en
dc.description.affiliationBarretos Canc Hosp, Mol Oncol Res Ctr, São Paulo, Brazil
dc.description.affiliationUniv Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal
dc.description.affiliationICVS 3Bs PT Govt Associate Lab, Braga, Portugal
dc.description.affiliationAC Camargo Hosp, Dept Gynecol Oncol, São Paulo, Brazil
dc.description.affiliationBarretos Canc Hosp, Dept Pathol, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Fac Med, Lab Med Invest LIM 14, São Paulo, Brazil
dc.description.affiliationAC Camargo Hosp, Dept Pathol, São Paulo, Brazil
dc.description.affiliationBarretos Canc Hosp, Dept Gynecol Oncol, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Fac Med, Lab Med Invest LIM 14, São Paulo, Brazil
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)
dc.description.sponsorshipIdFCT: SFRH/BD/36463/2007
dc.format.extent122-128
dc.identifierhttp://dx.doi.org/10.1136/jclinpath-2011-200358
dc.identifier.citationJournal of Clinical Pathology. London: Bmj Publishing Group, v. 65, n. 2, p. 122-128, 2012.
dc.identifier.doi10.1136/jclinpath-2011-200358
dc.identifier.issn0021-9746
dc.identifier.urihttp://hdl.handle.net/11449/41507
dc.identifier.wosWOS:000299821200006
dc.language.isoeng
dc.publisherB M J Publishing Group
dc.relation.ispartofJournal of Clinical Pathology
dc.relation.ispartofjcr2.894
dc.relation.ispartofsjr1,050
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.titleLoss of RKIP expression during the carcinogenic evolution of endometrial canceren
dc.typeArtigopt
dcterms.licensehttp://www.bmj.com/about-bmj/resources-authors
dcterms.rightsHolderBmj Publishing Group
dspace.entity.typePublication
unesp.author.orcid0000-0002-8193-5582[5]
unesp.author.orcid0000-0003-1647-7842[7]
unesp.author.orcid0000-0002-5235-6469[8]
unesp.author.orcid0000-0002-3221-0403[1]
unesp.author.orcid0000-0002-8920-6579[3]
unesp.author.orcid0000-0002-5779-9752[4]
unesp.author.orcid0000-0002-9639-7940[9]
unesp.author.orcid0000-0002-2029-5139[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt

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