Logotipo do repositório
 

Publicação:
Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2

Carregando...
Imagem de Miniatura

Orientador

Coorientador

Pós-graduação

Curso de graduação

Título da Revista

ISSN da Revista

Título de Volume

Editor

Sage Publications Inc

Tipo

Artigo

Direito de acesso

Acesso restrito

Resumo

The osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and tumor necrosis factor-a (TNF-alpha). In the present study, we investigated whether signaling through Toll-like receptor 2 (TLR2) can affect the expression of these cytokines in human gingival fibroblasts. Lipopolysaccharide (LPS) from P. gingivalis was found to stimulate IL-6 and LIF mRNA and protein, but not IL-11 or OSM mRNA. Using two synthetic ligands acting specifically at TLR2 and siRNA knockdown of TLR2, we demonstrated the important role of TLR2 in the stimulation of IL-6 and LIF in gingival fibroblasts. Analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts.

Descrição

Palavras-chave

gingival fibroblasts, IL-6, LIF, IL-11, TLR

Idioma

Inglês

Como citar

Journal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 89, n. 8, p. 802-807, 2010.

Itens relacionados

Unidades

Unidade
Faculdade de Odontologia
FOAR
Campus: Araraquara

Departamentos

Cursos de graduação

Programas de pós-graduação