Publicação: Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2
dc.contributor.author | Souza, Pedro Paulo Chaves de [UNESP] | |
dc.contributor.author | Palmqvist, P. | |
dc.contributor.author | Lundgren, I. | |
dc.contributor.author | Lie, A. | |
dc.contributor.author | Costa-Neto, C. M. [UNESP] | |
dc.contributor.author | Lundberg, P. | |
dc.contributor.author | Lerner, U. H. | |
dc.contributor.institution | Umea Univ | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Sahlgrens Acad | |
dc.date.accessioned | 2014-05-20T13:46:08Z | |
dc.date.available | 2014-05-20T13:46:08Z | |
dc.date.issued | 2010-08-01 | |
dc.description.abstract | The osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and tumor necrosis factor-a (TNF-alpha). In the present study, we investigated whether signaling through Toll-like receptor 2 (TLR2) can affect the expression of these cytokines in human gingival fibroblasts. Lipopolysaccharide (LPS) from P. gingivalis was found to stimulate IL-6 and LIF mRNA and protein, but not IL-11 or OSM mRNA. Using two synthetic ligands acting specifically at TLR2 and siRNA knockdown of TLR2, we demonstrated the important role of TLR2 in the stimulation of IL-6 and LIF in gingival fibroblasts. Analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts. | en |
dc.description.affiliation | Umea Univ, Dept Oral Cell Biol, S-90187 Umea, Sweden | |
dc.description.affiliation | São Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, São Paulo, Brazil | |
dc.description.affiliation | Sahlgrens Acad, Inst Med, Ctr Bone & Arthrit Res, Gothenburg, Sweden | |
dc.description.affiliationUnesp | São Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, São Paulo, Brazil | |
dc.description.sponsorship | Swedish Science Council | |
dc.description.sponsorship | Swedish Rheumatism Association | |
dc.description.sponsorship | Royal 80 Year Fund of King Gustav V | |
dc.description.sponsorship | County Council of Vasterbotten | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | Swedish Science Council: 07525 | |
dc.description.sponsorshipId | CAPES: 5189063 | |
dc.format.extent | 802-807 | |
dc.identifier | http://dx.doi.org/10.1177/0022034510366898 | |
dc.identifier.citation | Journal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 89, n. 8, p. 802-807, 2010. | |
dc.identifier.doi | 10.1177/0022034510366898 | |
dc.identifier.issn | 0022-0345 | |
dc.identifier.uri | http://hdl.handle.net/11449/16296 | |
dc.identifier.wos | WOS:000280194800008 | |
dc.language.iso | eng | |
dc.publisher | Sage Publications Inc | |
dc.relation.ispartof | Journal of Dental Research | |
dc.relation.ispartofjcr | 5.380 | |
dc.relation.ispartofsjr | 2,302 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | gingival fibroblasts | en |
dc.subject | IL-6 | en |
dc.subject | LIF | en |
dc.subject | IL-11 | en |
dc.subject | TLR | en |
dc.title | Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2 | en |
dc.type | Artigo | |
dcterms.license | https://mc.manuscriptcentral.com/societyimages/wes/WES_ExclusiveLicense.pdf | |
dcterms.rightsHolder | Sage Publications Inc | |
dspace.entity.type | Publication | |
unesp.author.orcid | 0000-0002-7256-6412[5] | |
unesp.author.orcid | 0000-0001-7266-6061[1] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara | pt |
unesp.department | Fisiologia e Patologia - FOAR | pt |
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