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Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2

dc.contributor.authorSouza, Pedro Paulo Chaves de [UNESP]
dc.contributor.authorPalmqvist, P.
dc.contributor.authorLundgren, I.
dc.contributor.authorLie, A.
dc.contributor.authorCosta-Neto, C. M. [UNESP]
dc.contributor.authorLundberg, P.
dc.contributor.authorLerner, U. H.
dc.contributor.institutionUmea Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSahlgrens Acad
dc.date.accessioned2014-05-20T13:46:08Z
dc.date.available2014-05-20T13:46:08Z
dc.date.issued2010-08-01
dc.description.abstractThe osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and tumor necrosis factor-a (TNF-alpha). In the present study, we investigated whether signaling through Toll-like receptor 2 (TLR2) can affect the expression of these cytokines in human gingival fibroblasts. Lipopolysaccharide (LPS) from P. gingivalis was found to stimulate IL-6 and LIF mRNA and protein, but not IL-11 or OSM mRNA. Using two synthetic ligands acting specifically at TLR2 and siRNA knockdown of TLR2, we demonstrated the important role of TLR2 in the stimulation of IL-6 and LIF in gingival fibroblasts. Analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts.en
dc.description.affiliationUmea Univ, Dept Oral Cell Biol, S-90187 Umea, Sweden
dc.description.affiliationSão Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, São Paulo, Brazil
dc.description.affiliationSahlgrens Acad, Inst Med, Ctr Bone & Arthrit Res, Gothenburg, Sweden
dc.description.affiliationUnespSão Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, São Paulo, Brazil
dc.description.sponsorshipSwedish Science Council
dc.description.sponsorshipSwedish Rheumatism Association
dc.description.sponsorshipRoyal 80 Year Fund of King Gustav V
dc.description.sponsorshipCounty Council of Vasterbotten
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdSwedish Science Council: 07525
dc.description.sponsorshipIdCAPES: 5189063
dc.format.extent802-807
dc.identifierhttp://dx.doi.org/10.1177/0022034510366898
dc.identifier.citationJournal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 89, n. 8, p. 802-807, 2010.
dc.identifier.doi10.1177/0022034510366898
dc.identifier.issn0022-0345
dc.identifier.urihttp://hdl.handle.net/11449/16296
dc.identifier.wosWOS:000280194800008
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Dental Research
dc.relation.ispartofjcr5.380
dc.relation.ispartofsjr2,302
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectgingival fibroblastsen
dc.subjectIL-6en
dc.subjectLIFen
dc.subjectIL-11en
dc.subjectTLRen
dc.titleStimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2en
dc.typeArtigo
dcterms.licensehttps://mc.manuscriptcentral.com/societyimages/wes/WES_ExclusiveLicense.pdf
dcterms.rightsHolderSage Publications Inc
dspace.entity.typePublication
unesp.author.orcid0000-0002-7256-6412[5]
unesp.author.orcid0000-0001-7266-6061[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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