Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
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Graduate program
Undergraduate course
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Publisher
Instituto Oswaldo Cruz, Ministério da Saúde
Type
Article
Access right
Acesso aberto
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Abstract
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.
Description
Keywords
protease, activated receptor-2, alveolar bone loss, inflammation, host response, Porphyromonas gingivalis, periodontitis
Language
English
Citation
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 100, p. 177-180, 2005.
