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Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis

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dc.contributor.authorHolzhausen, M. [UNESP]
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.authorVergnolle, N.
dc.contributor.institutionUniversity of Calgary
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAlberta Heritage Foundation for Medical Research Scholar
dc.contributor.institutionCanadian Institute for Health Research Investigator
dc.date.accessioned2014-05-20T13:46:13Z
dc.date.available2014-05-20T13:46:13Z
dc.date.issued2005-03-01
dc.description.abstractProteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.en
dc.description.affiliationUniversity of Calgary Faculty of Medicine Department of Pharmacology and Therapeutics
dc.description.affiliationUniversidade Estadual de São Paulo Escola Dental de Araraquara Departamento de Periodontologia e Patologia Oral
dc.description.affiliationAlberta Heritage Foundation for Medical Research Scholar
dc.description.affiliationCanadian Institute for Health Research Investigator
dc.format.extent177-180
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762005000900030
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 100, p. 177-180, 2005.
dc.identifier.doi10.1590/S0074-02762005000900030
dc.identifier.fileS0074-02762005000900030.pdf
dc.identifier.issn0074-0276
dc.identifier.lattes2640929291808415
dc.identifier.scieloS0074-02762005000900030
dc.identifier.urihttp://hdl.handle.net/11449/16332
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.relation.ispartofjcr2.833
dc.relation.ispartofsjr1,172
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectproteaseen
dc.subjectactivated receptor-2en
dc.subjectalveolar bone lossen
dc.subjectinflammationen
dc.subjecthost responseen
dc.subjectPorphyromonas gingivalisen
dc.subjectperiodontitisen
dc.titleRole of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitisen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes2640929291808415
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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Coleções

Araraquara - FOAR - Faculdade de Odontologia