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Publicação:
Cardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in rats

dc.contributor.authorSimas, Bruna B.
dc.contributor.authorNunes, Everson A.
dc.contributor.authorCrestani, Carlos C. [UNESP]
dc.contributor.authorSperetta, Guilherme F.
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:51:51Z
dc.date.available2018-12-11T16:51:51Z
dc.date.issued2018-05-04
dc.description.abstractObesity and chronic stress are considered independent risk factors for the development of cardiovascular diseases and changes in autonomic system activity. However, the cardiovascular consequences induced by the association between high-fat diet (HFD) and chronic stress are not fully understood. We hypothesized that the association between HFD and exposure to a chronic variable stress (CVS) protocol for four weeks might exacerbate the cardiovascular and metabolic disturbances in rats when compared to these factors singly. To test this hypothesis, male Wistar rats were divided into four groups: control-standard chow diet (SD; n = 8); control-HFD (n = 8); CVS-SD (n = 8); and CVS-HFD (n = 8). The CVS consisted of repeated exposure of the rats to different inescapable and unpredictable stressors (restraint tress; damp sawdust, cold, swim stress and light cycle inversion). We evaluated cardiovascular function, autonomic activity, dietary intake, adiposity and metabolism. The HFD increased body weight, adiposity and blood glucose concentration (∼15%) in both control and CVS rats. The CVS–HFD rats showed decreased insulin sensitivity (25%) compared to CVS–SD rats. The control-HFD and CVS–HFD rats presented increased intrinsic heart rate (HR) values (∼8%). CVS increased cardiac sympathetic activity (∼65%) in both SD- and HFD-fed rats. The HFD increased basal HR (∼10%). Blood pressure and baroreflex analyzes showed no differences among the experimental groups. In conclusion, the present data indicate absence of interaction on autonomic imbalance evoked by either CVS or HFD. Additionally, HFD increased HR and evoked metabolic disruptions which are independent of stress exposure.en
dc.description.affiliationDepartment of Physiological Sciences Biological Sciences Centre Federal University of Santa Catarina (UFSC)
dc.description.affiliationLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationUnespLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.format.extent247-256
dc.identifierhttp://dx.doi.org/10.1080/10253890.2018.1437413
dc.identifier.citationStress, v. 21, n. 3, p. 247-256, 2018.
dc.identifier.doi10.1080/10253890.2018.1437413
dc.identifier.issn1607-8888
dc.identifier.issn1025-3890
dc.identifier.scopus2-s2.0-85041799265
dc.identifier.urihttp://hdl.handle.net/11449/170650
dc.language.isoeng
dc.relation.ispartofStress
dc.relation.ispartofsjr1,260
dc.relation.ispartofsjr1,260
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectAdipose stores
dc.subjectautonomic activity
dc.subjectbaroreflex activity
dc.subjectchronic variable stress
dc.subjectinsulin resistance
dc.subjectintrinsic heart rate
dc.titleCardiovascular and metabolic consequences of the association between chronic stress and high-fat diet in ratsen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes1117432571971568[3]
unesp.author.orcid0000-0002-1942-858X[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt

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