Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats
dc.contributor.author | Dela Cruz, Cynthia | |
dc.contributor.author | Pereira, Oduvaldo C. M. [UNESP] | |
dc.contributor.institution | Universidade Federal de Minas Gerais (UFMG) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T15:32:58Z | |
dc.date.available | 2014-05-20T15:32:58Z | |
dc.date.issued | 2012-03-01 | |
dc.description.abstract | The objective of this study was to investigate whether prenatal exposure to testosterone (T) could change the body weight (BW), anogenital distance (AGD), anogenital distance index (AGDI), puberty onset, social behavior, fertility, sexual behavior, sexual preference, and T level of male rats in adulthood. To test this hypothesis, pregnant rats received either 1 mg/animal of T propionate diluted in 0.1 ml peanut oil or 0.1 ml peanut oil, as control, on the 17th, 18th and 19th gestational days. No alterations in BW, AGD, AGDI, fertility, and sexual behavior were observed (p > 0.05). Delayed onset of puberty (p < 0.0001), increased aggressive behavior (p > 0.05), altered pattern of sexual preference (p < 0.05), and reduced T plasma level (p < 0.05) were observed for adult male rats exposed prenatally to T. In conclusion, the results showed that prenatal exposure to T was able to alter important aspects of sexual and social behavior although these animals were efficient at producing descendants. In this sense more studies should be carried to evaluated the real impact of this hormonal alteration on critical period of sexual differentiation on humans, because pregnant women exposed to hyperandrogenemia and then potentially exposing their unborn children to elevated androgen levels in the uterus can undergo alteration of normal levels of T during the sexual differentiation period, and, as a consequence, affect the reproductive and behavior patterns of their children in adulthood. | en |
dc.description.affiliation | Universidade Federal de Minas Gerais (UFMG), Dept Ob Gyn, Hosp Clin, Div Human Reprod, BR-30130100 Belo Horizonte, MG, Brazil | |
dc.description.affiliation | Universidade Federal de Minas Gerais (UFMG), Dept Physiol & Biophys, Inst Biol Sci, BR-30130100 Belo Horizonte, MG, Brazil | |
dc.description.affiliation | São Paulo State Univ, UNESP, Dept Pharmacol, Inst Biosci, São Paulo, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ, UNESP, Dept Pharmacol, Inst Biosci, São Paulo, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.format.extent | 123-131 | |
dc.identifier | http://dx.doi.org/10.1007/s12576-011-0190-7 | |
dc.identifier.citation | Journal of Physiological Sciences. Tokyo: Springer Tokyo, v. 62, n. 2, p. 123-131, 2012. | |
dc.identifier.doi | 10.1007/s12576-011-0190-7 | |
dc.identifier.issn | 1880-6546 | |
dc.identifier.uri | http://hdl.handle.net/11449/41730 | |
dc.identifier.wos | WOS:000300774300005 | |
dc.language.iso | eng | |
dc.publisher | Springer Tokyo | |
dc.relation.ispartof | Journal of Physiological Sciences | |
dc.relation.ispartofjcr | 2.757 | |
dc.relation.ispartofsjr | 1,029 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Aggressive behavior | en |
dc.subject | Male rats | en |
dc.subject | Prenatal testosterone | en |
dc.subject | Puberty onset | en |
dc.subject | Sexual behavior | en |
dc.subject | Sexual differentiation | en |
dc.title | Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats | en |
dc.type | Artigo | |
dcterms.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
dcterms.rightsHolder | Springer Tokyo | |
dspace.entity.type | Publication | |
unesp.author.orcid | 0000-0002-1236-9142[1] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatu | pt |
unesp.department | Farmacologia - IBB | pt |
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