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Prenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male rats

dc.contributor.authorDela Cruz, Cynthia
dc.contributor.authorPereira, Oduvaldo C. M. [UNESP]
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:58Z
dc.date.available2014-05-20T15:32:58Z
dc.date.issued2012-03-01
dc.description.abstractThe objective of this study was to investigate whether prenatal exposure to testosterone (T) could change the body weight (BW), anogenital distance (AGD), anogenital distance index (AGDI), puberty onset, social behavior, fertility, sexual behavior, sexual preference, and T level of male rats in adulthood. To test this hypothesis, pregnant rats received either 1 mg/animal of T propionate diluted in 0.1 ml peanut oil or 0.1 ml peanut oil, as control, on the 17th, 18th and 19th gestational days. No alterations in BW, AGD, AGDI, fertility, and sexual behavior were observed (p > 0.05). Delayed onset of puberty (p < 0.0001), increased aggressive behavior (p > 0.05), altered pattern of sexual preference (p < 0.05), and reduced T plasma level (p < 0.05) were observed for adult male rats exposed prenatally to T. In conclusion, the results showed that prenatal exposure to T was able to alter important aspects of sexual and social behavior although these animals were efficient at producing descendants. In this sense more studies should be carried to evaluated the real impact of this hormonal alteration on critical period of sexual differentiation on humans, because pregnant women exposed to hyperandrogenemia and then potentially exposing their unborn children to elevated androgen levels in the uterus can undergo alteration of normal levels of T during the sexual differentiation period, and, as a consequence, affect the reproductive and behavior patterns of their children in adulthood.en
dc.description.affiliationUniversidade Federal de Minas Gerais (UFMG), Dept Ob Gyn, Hosp Clin, Div Human Reprod, BR-30130100 Belo Horizonte, MG, Brazil
dc.description.affiliationUniversidade Federal de Minas Gerais (UFMG), Dept Physiol & Biophys, Inst Biol Sci, BR-30130100 Belo Horizonte, MG, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Pharmacol, Inst Biosci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Pharmacol, Inst Biosci, São Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent123-131
dc.identifierhttp://dx.doi.org/10.1007/s12576-011-0190-7
dc.identifier.citationJournal of Physiological Sciences. Tokyo: Springer Tokyo, v. 62, n. 2, p. 123-131, 2012.
dc.identifier.doi10.1007/s12576-011-0190-7
dc.identifier.issn1880-6546
dc.identifier.urihttp://hdl.handle.net/11449/41730
dc.identifier.wosWOS:000300774300005
dc.language.isoeng
dc.publisherSpringer Tokyo
dc.relation.ispartofJournal of Physiological Sciences
dc.relation.ispartofjcr2.757
dc.relation.ispartofsjr1,029
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAggressive behavioren
dc.subjectMale ratsen
dc.subjectPrenatal testosteroneen
dc.subjectPuberty onseten
dc.subjectSexual behavioren
dc.subjectSexual differentiationen
dc.titlePrenatal testosterone supplementation alters puberty onset, aggressive behavior, and partner preference in adult male ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer Tokyo
dspace.entity.typePublication
unesp.author.orcid0000-0002-1236-9142[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt

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