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Mild diabetes: long-term effects on gastric motility evaluated in rats

dc.contributor.authorHauschildt, Andrieli T.
dc.contributor.authorCorá, Luciana A.
dc.contributor.authorVolpato, Gustavo T.
dc.contributor.authorSinzato, Yuri K. [UNESP]
dc.contributor.authorDamasceno, Débora C. [UNESP]
dc.contributor.authorAmérico, Madileine F.
dc.contributor.institutionFederal University of Mato Grosso – UFMT
dc.contributor.institutionAlagoas State University of Health Sciences – UNCISAL
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:52:02Z
dc.date.available2018-12-11T16:52:02Z
dc.date.issued2018-02-01
dc.description.abstractModerate hyperglycaemic levels seem to be related to abnormal gastric motility in diabetes mellitus. However, experimental models designed to evaluate the relationship between motility and diabetes over time are not yet well established. Our objective was to investigate the long-term effects of mild diabetes on gastric motility in rats. Newborn male rats received streptozotocin (mild diabetes groups – MD) or vehicle (control groups – C), and both groups were evaluated after 3 (C3 and MD3) and 6 months (C6 and MD6) postinduction. Mild diabetic animals (MD3 and MD6) showed moderately elevated blood glucose and decreased insulin levels compared with control (C3 and C6). Insulin secretion was enhanced in MD6 compared with MD3, most likely due to partial β-cell regeneration indicated by HOMA-β. In HOMA-IR, it was noticed that MD6 animals had impaired insulin response compared with MD3. Gastric emptying was faster, amplitude of contraction was stronger in MD6 compared with MD3, and in both groups, the differences were significant when compared with control animals. A significant abnormal rhythmic index was calculated for the mild diabetic groups, despite unchanged mean frequency of contraction. In conclusion, despite increased insulin levels over time, constant levels of moderate hyperglycaemia are also related to abnormal gastric motility and impairment of gastric function.en
dc.description.affiliationFederal University of Mato Grosso – UFMT
dc.description.affiliationAlagoas State University of Health Sciences – UNCISAL
dc.description.affiliationSao Paulo State University UNESP
dc.description.affiliationUnespSao Paulo State University UNESP
dc.format.extent29-37
dc.identifierhttp://dx.doi.org/10.1111/iep.12262
dc.identifier.citationInternational Journal of Experimental Pathology, v. 99, n. 1, p. 29-37, 2018.
dc.identifier.doi10.1111/iep.12262
dc.identifier.issn1365-2613
dc.identifier.issn0959-9673
dc.identifier.scopus2-s2.0-85042427070
dc.identifier.urihttp://hdl.handle.net/11449/170696
dc.language.isoeng
dc.relation.ispartofInternational Journal of Experimental Pathology
dc.relation.ispartofsjr0,712
dc.relation.ispartofsjr0,712
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectexperimental diabetes
dc.subjectgastric emptying
dc.subjectmoderate hyperglycaemia
dc.subjectmotility disorders
dc.subjectstomach contractions
dc.titleMild diabetes: long-term effects on gastric motility evaluated in ratsen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0003-3058-0504[1]

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