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Microwave Denture Disinfection Versus Nystatin in Treating Patients with Well-Controlled Type 2 Diabetes and Denture Stomatitis: A Randomized Clinical Trial

dc.contributor.authorSanita, Paula Volpato
dc.contributor.authorMachado, Ana Lucia [UNESP]
dc.contributor.authorPavarina, Ana Claudia [UNESP]
dc.contributor.authorMassucato, Elaine Maria Sgavioli [UNESP]
dc.contributor.authorColombo, Arnaldo Lopes
dc.contributor.authorVergani, Carlos Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2013-09-30T18:33:11Z
dc.date.accessioned2014-05-20T13:45:11Z
dc.date.available2013-09-30T18:33:11Z
dc.date.available2014-05-20T13:45:11Z
dc.date.issued2012-05-01
dc.description.abstractPurpose: The aim of this randomized clinical trial was to compare the effectiveness of microwave denture disinfection and nystatin in the treatment of well-controlled type 2 diabetic patients with denture stomatitis in terms of microbiologic and clinical outcomes. Materials and Methods: Diabetic patients wearing maxillary complete dentures with denture stomatitis (n = 40) were divided into two groups: NYS (patients treated with topical nystatin 4 times/day for 14 days) and MW (patients who had their dentures microwaved [650 W for 3 minutes] 3 times/week for 14 days). Mycologic samples were taken from the palates and dentures of the patients for quantification and identification of Candida, and standardized photographs of the palates were taken for clinical analysis. Evaluations were repeated at baseline, the end of treatment (day 14), and throughout follow-up (days 30, 60, and 90). Microbiologic data were evaluated by analysis of variance using a random effects statistical model, Tukey post hoc test, and chi-square test (alpha = .05). Clinical resuts were analyzed using Mann-Whitney and Fisher exact tests (alpha = .05). Results:, Both treatments were considered successful in reducing the clinical signs of denture stomatitis and significantly reduced the values of colony-forming units/mL from the palates and dentures at days 14 and 30. In addition, 40% of treated patients were cured by the end of treatment. No significant differences in the microbiologic and clinical outcomes were revealed between the two groups (P > .05). C alb/cans was the most predominant species isolated (P < .01), followed by C tropicalis and C glabrata. Conclusion: Denture microwave disinfection was as effective as nystatin for the treatment of diabetic patients with denture stomatitis. Int J Prosthodont 2012;25:232-244.en
dc.description.affiliationUNESP Univ Estadual Paulista, Araraquara Dent Sch, Dept Dent Mat & Prosthodont, BR-14801903 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Araraquara Dent Sch, Dept Dent Mat & Prosthodont, BR-14801903 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 06/02842-5
dc.description.sponsorshipIdFAPESP: 07/03895-8
dc.description.sponsorshipIdCNPq: 470337/2007-9
dc.format.extent232-244
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22545252
dc.identifier.citationInternational Journal of Prosthodontics. Hanover Park: Quintessence Publishing Co Inc, v. 25, n. 3, p. 232-244, 2012.
dc.identifier.issn0893-2174
dc.identifier.lattes8000248781842587
dc.identifier.lattes8867670539105403
dc.identifier.lattes3003130522427820
dc.identifier.orcid0000-0002-7375-4714
dc.identifier.urihttp://hdl.handle.net/11449/15881
dc.identifier.wosWOS:000304181900005
dc.language.isoeng
dc.publisherQuintessence Publishing Co Inc
dc.relation.ispartofInternational Journal of Prosthodontics
dc.relation.ispartofjcr1.333
dc.relation.ispartofsjr0,891
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.titleMicrowave Denture Disinfection Versus Nystatin in Treating Patients with Well-Controlled Type 2 Diabetes and Denture Stomatitis: A Randomized Clinical Trialen
dc.typeArtigopt
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderQuintessence Publishing Co Inc
dspace.entity.typePublication
relation.isDepartmentOfPublication3936e2e2-946a-42ab-8b9d-9521513200fc
relation.isDepartmentOfPublication.latestForDiscovery3936e2e2-946a-42ab-8b9d-9521513200fc
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.author.lattes8000248781842587[2]
unesp.author.lattes8867670539105403[3]
unesp.author.lattes3003130522427820[6]
unesp.author.orcid0000-0002-7375-4714[6]
unesp.author.orcid0000-0002-9231-1994[3]
unesp.author.orcid0000-0002-2718-428X[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentMateriais Odontológicos e Prótese - FOARpt

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