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Nanostructured lipid system as a strategy to improve the anti-Candida albicans activity of Astronium sp

dc.contributor.authorBonifácio, Bruna Vidal [UNESP]
dc.contributor.authorRamos, Matheus Aparecido dos Santos [UNESP]
dc.contributor.authorSilva, Patrícia Bento da [UNESP]
dc.contributor.authorNegri, Kamila Maria Silveira [UNESP]
dc.contributor.authorOliveira Lopes, Érica de [UNESP]
dc.contributor.authorSouza, Leonardo Perez de [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorBauab, Taís Maria [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:34:37Z
dc.date.available2015-12-07T15:34:37Z
dc.date.issued2015
dc.description.abstractThe genus Astronium (Anacardiaceae) includes species, such as Astronium fraxinifolium, Astronium graveolens, and Astronium urundeuva, which possess anti-inflammatory, anti-ulcerogenic, healing, and antimicrobial properties. Nanostructured lipid systems are able to potentiate the action of plant extracts, reducing the required dose and side effects and improving antimicrobial activity. This work aims to evaluate a nanostructured lipid system that was developed as a strategy to improve the anti-Candida albicans activity of hydroethanolic extracts of stems and leaves from Astronium sp. The antifungal activity against C. albicans (ATCC 18804) was evaluated in vitro by a microdilution technique. In addition to the in vitro assays, the Astronium sp. that showed the best antifungal activity and selectivity index was submitted to an in vivo assay using a model of vulvovaginal candidiasis infection. In these assays, the extracts were either used alone or were incorporated into the nanostructured lipid system (comprising 10% oil phase, 10% surfactant, and 80% aqueous phase). The results indicated a minimal inhibitory concentration of 125.00 µg/mL before incorporation into the nanostructured system; this activity was even more enhanced when this extract presented a minimal inhibitory concentration of 15.62 µg/mL after its incorporation. In vivo assay dates showed that the nanostructure-incorporated extract of A. urundeuva leaves was more effective than both the unincorporated extract and the antifungal positive control (amphotericin B). These results suggest that this nanostructured lipid system can be used in a strategy to improve the in vitro and in vivo anti-C. albicans activity of hydroethanolic extracts of Astronium sp.en
dc.description.affiliationDepartment of Biological Sciences, School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
dc.description.affiliationDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
dc.description.affiliationDepartment of Organic Chemistry, Chemistry Institute, UNESP - Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
dc.description.affiliationCoastal Campus of São Vicente, UNESP - Univ Estadual Paulista, São Vicente, São Paulo, Brazil.
dc.description.affiliationUnespDepartment of Biological Sciences, School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
dc.description.affiliationUnespDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
dc.description.affiliationUnespDepartment of Organic Chemistry, Chemistry Institute, UNESP - Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
dc.description.affiliationUnespCoastal Campus of São Vicente, UNESP - Univ Estadual Paulista, São Vicente, São Paulo, Brazil.
dc.format.extent5081-5092
dc.identifierhttp://dx.doi.org/10.2147/IJN.S79684
dc.identifier.citationInternational Journal Of Nanomedicine, v. 10, p. 5081-5092, 2015.
dc.identifier.doi10.2147/IJN.S79684
dc.identifier.filePMC4536841.pdf
dc.identifier.issn1178-2013
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.pmcPMC4536841
dc.identifier.pubmed26300640
dc.identifier.urihttp://hdl.handle.net/11449/131383
dc.language.isoeng
dc.publisherInternational Journal Of Nanomedicine
dc.relation.ispartofInternational Journal Of Nanomedicine
dc.relation.ispartofjcr4.370
dc.relation.ispartofsjr1,225
dc.rights.accessRightsAcesso abertopt
dc.sourcePubMed
dc.subjectAnticandidal activityen
dc.subjectMicrodilutionen
dc.subjectMicroemulsionen
dc.subjectPlant extracten
dc.subjectVulvovaginal candidiasisen
dc.titleNanostructured lipid system as a strategy to improve the anti-Candida albicans activity of Astronium spen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublication5004bcab-94af-4939-b980-091ae9d0a19e
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscovery5004bcab-94af-4939-b980-091ae9d0a19e
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0003-3032-2556[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt
unesp.departmentCiências Biológicas - IBCLPpt
unesp.departmentQuímica Orgânica - IQARpt

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