Publication: Parkinson's disease effect on autonomic modulation: an analysis using geometric indices
Loading...
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Assoc Arquivos Neuro- Psiquiatria
Type
Article
Access right
Acesso aberto
Abstract
Background: Parkinson's disease (PD) produces autonomic changes, indicating lower parasympathetic modulation and global variability, but these changes need further studying regarding geometric methods. Objective: To investigate the autonomic modulation in individuals with PD using heart rate variability (HRV) indices obtained through geometric methods. Methods: This is a cross-sectional study that assessed 50 individuals, split into two groups: PD group (PDG; n=26; 75.36 +/- 5.21 years) and control group (CG; n=24; 75.36 +/- 5.21 years). We evaluated the autonomic modulation by measuring the heart rate beat-to-beat for 30 min with the individual in supine rest using a heart rate monitor and assessed geometric indices (RRtri, TINN, SD1, SD2, SD1/SD2 ratio, and qualitative analysis of the Poincare plot). Results: Significant reductions were found in RRtri, TINN, SD1, and SD2 indices among PDG compared to CG. Regarding the SD1/SD2 ratio, no significant changes were detected between the groups. The Poincare plot demonstrated that individuals with PD had lower beat-to-beat dispersion in RR intervals, in addition to greater long-term dispersion of RR intervals compared to CG. Conclusions: The results suggest a reduction in the parasympathetic autonomic modulation and global variability in individuals with PD compared to controls, regardless of sex, age, and body mass
Description
Keywords
Parkinson Disease, Autonomic Nervous System, Primary Dysautonomias, Neurodegenerative Diseases
Language
English
Citation
Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos Neuro- Psiquiatria, v. 79, n. 2, p. 114-121, 2021.
