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Environmentally induced antinociception and hyperalgesia in rats and mice

dc.contributor.authorCornelio, Alianda Maira [UNESP]
dc.contributor.authorMendes-Gomes, Joyce [UNESP]
dc.contributor.authorFugimoto, Juliana Sayuri [UNESP]
dc.contributor.authorMorgan, Michael M.
dc.contributor.authorNunes-de-Souza, Ricardo Luiz [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionWashington State Univ Vancouver
dc.date.accessioned2014-05-20T15:34:32Z
dc.date.available2014-05-20T15:34:32Z
dc.date.issued2011-09-30
dc.description.abstractStress can enhance and inhibit nociception depending on the situation. Thus, simply shifting the context from the elevated plus maze (EPM) which has been shown to produce stress-induced antinociception to a different environment could produce drastic and rapid changes in nociception. The present experiment tested this hypothesis by assessing nociception in rats and mice during and immediately after removal from the maze. Experiment 1 found hyperalgesia in female and male rats tested on the hot plate immediately after exposure to the elevated plus maze. This hyperalgesia occurred with or without the added stress of a hind paw formalin injection and regardless of whether rats were exposed to an EPM with open (oEPM) or enclosed (eEPM) arms despite a clear antinociceptive effect while on the oEPM. Experiment 2 showed a similar shift from antinociception to nociception on the formalin test in mice immediately after removing them from the EPM. These data demonstrate that a mild stressor such as the EPM can produce both antinociception and hyperalgesia depending on the context. This shift from antinociception to hyperalgesia occurs rapidly and is evident in mice, male and female rats, and with the hot plate and formalin tests. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, UFSCar, Programa Interinst Posgrad Ciencias Fisiol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUSP, FFCLRP, Programa Posgrad Psicobiol, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationWashington State Univ Vancouver, Dept Psychol, Vancouver, WA 98686 USA
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, UFSCar, Programa Interinst Posgrad Ciencias Fisiol, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipState of Washington Initiative Measure
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdState of Washington Initiative Measure: 171
dc.description.sponsorshipIdCNPq: 200639/ 2008-0
dc.description.sponsorshipIdCNPq: 116260/2007-6
dc.description.sponsorshipIdCNPq: 303580/2009-7
dc.description.sponsorshipIdFAPESP: 05/01988-3
dc.format.extent56-62
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2011.07.058
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1415, p. 56-62, 2011.
dc.identifier.doi10.1016/j.brainres.2011.07.058
dc.identifier.fileWOS000295708500006.pdf
dc.identifier.issn0006-8993
dc.identifier.urihttp://hdl.handle.net/11449/42568
dc.identifier.wosWOS:000295708500006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectEnvironmentally induced antinociceptionen
dc.subjectHyperalgesiaen
dc.subjectSex differenceen
dc.subjectElevated plus mazeen
dc.subjectPain modulationen
dc.subjectRat and mouseen
dc.titleEnvironmentally induced antinociception and hyperalgesia in rats and miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0001-5762-2538[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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