Publicação: Environmentally induced antinociception and hyperalgesia in rats and mice
dc.contributor.author | Cornelio, Alianda Maira [UNESP] | |
dc.contributor.author | Mendes-Gomes, Joyce [UNESP] | |
dc.contributor.author | Fugimoto, Juliana Sayuri [UNESP] | |
dc.contributor.author | Morgan, Michael M. | |
dc.contributor.author | Nunes-de-Souza, Ricardo Luiz [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Washington State Univ Vancouver | |
dc.date.accessioned | 2014-05-20T15:34:32Z | |
dc.date.available | 2014-05-20T15:34:32Z | |
dc.date.issued | 2011-09-30 | |
dc.description.abstract | Stress can enhance and inhibit nociception depending on the situation. Thus, simply shifting the context from the elevated plus maze (EPM) which has been shown to produce stress-induced antinociception to a different environment could produce drastic and rapid changes in nociception. The present experiment tested this hypothesis by assessing nociception in rats and mice during and immediately after removal from the maze. Experiment 1 found hyperalgesia in female and male rats tested on the hot plate immediately after exposure to the elevated plus maze. This hyperalgesia occurred with or without the added stress of a hind paw formalin injection and regardless of whether rats were exposed to an EPM with open (oEPM) or enclosed (eEPM) arms despite a clear antinociceptive effect while on the oEPM. Experiment 2 showed a similar shift from antinociception to nociception on the formalin test in mice immediately after removing them from the EPM. These data demonstrate that a mild stressor such as the EPM can produce both antinociception and hyperalgesia depending on the context. This shift from antinociception to hyperalgesia occurs rapidly and is evident in mice, male and female rats, and with the hot plate and formalin tests. (C) 2011 Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | UNESP, Fac Ciencias Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliation | UNESP, UFSCar, Programa Interinst Posgrad Ciencias Fisiol, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliation | USP, FFCLRP, Programa Posgrad Psicobiol, BR-14040901 Ribeirao Preto, SP, Brazil | |
dc.description.affiliation | Washington State Univ Vancouver, Dept Psychol, Vancouver, WA 98686 USA | |
dc.description.affiliationUnesp | UNESP, Fac Ciencias Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, UFSCar, Programa Interinst Posgrad Ciencias Fisiol, BR-14801902 Araraquara, SP, Brazil | |
dc.description.sponsorship | State of Washington Initiative Measure | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Programa de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | State of Washington Initiative Measure: 171 | |
dc.description.sponsorshipId | CNPq: 200639/ 2008-0 | |
dc.description.sponsorshipId | CNPq: 116260/2007-6 | |
dc.description.sponsorshipId | CNPq: 303580/2009-7 | |
dc.description.sponsorshipId | FAPESP: 05/01988-3 | |
dc.format.extent | 56-62 | |
dc.identifier | http://dx.doi.org/10.1016/j.brainres.2011.07.058 | |
dc.identifier.citation | Brain Research. Amsterdam: Elsevier B.V., v. 1415, p. 56-62, 2011. | |
dc.identifier.doi | 10.1016/j.brainres.2011.07.058 | |
dc.identifier.file | WOS000295708500006.pdf | |
dc.identifier.issn | 0006-8993 | |
dc.identifier.uri | http://hdl.handle.net/11449/42568 | |
dc.identifier.wos | WOS:000295708500006 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Brain Research | |
dc.relation.ispartofjcr | 3.125 | |
dc.relation.ispartofsjr | 1,404 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | Environmentally induced antinociception | en |
dc.subject | Hyperalgesia | en |
dc.subject | Sex difference | en |
dc.subject | Elevated plus maze | en |
dc.subject | Pain modulation | en |
dc.subject | Rat and mouse | en |
dc.title | Environmentally induced antinociception and hyperalgesia in rats and mice | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
dspace.entity.type | Publication | |
unesp.author.orcid | 0000-0001-5762-2538[1] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara | pt |
unesp.department | Fisiologia e Patologia - FOAR | pt |
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