Comparative In Vitro study on the susceptibility and emergence of mutants resistant to danofloxacin and ciprofloxacin among Staphylococcus Aureus isolated from bovine mastitis

Cruz, Andrea D. [UNESP]; De Magalhães Lopes, Carlos A. [UNESP]; Modolo, José R. [UNESP]; Gottschalk, Arnold F. [UNESP]

Comparative In Vitro study on the susceptibility and emergence of mutants resistant to danofloxacin and ciprofloxacin among Staphylococcus Aureus isolated from bovine mastitis

Data

1997-12-01

Autores

Cruz, Andrea D.

De Magalhães Lopes, Carlos A.

Modolo, José R.

Gottschalk, Arnold F.

Tipo

Artigo

Resumo

The antimicrobial susceptibility of danofloxacin was compared in vitro with ciprofloxacin against mastitogenic Staphylococcus aureus Danofloxacin was more active than ciprofloxacin, showing minimal inhibitory concentrations (MIC90), minimal bactericidal concentrations (MBC90) and MBC/MIC ratio lower than those of ciprofloxacin. Ciprofloxacin-resistant mutants occurred at higher frequencies (≥10-6) than for danofloxacin (10-9).