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Synthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes

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dc.contributor.authorCavicchioli, Mauricio
dc.contributor.authorLeite, Clarice Q. F.
dc.contributor.authorSato, Daisy N.
dc.contributor.authorMassabni, Antonio Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.date.accessioned2014-05-20T13:24:31Z
dc.date.available2014-05-20T13:24:31Z
dc.date.issued2007-10-01
dc.description.abstractThe present work describes the synthesis and antimycobacterial activity of three Ag(I)-complexes with the sweeteners aspartame, saccharin, and cyclamate as ligands, with the aim of finding new candidate substances for fighting tuberculosis and other mycobacterial infections. The minimal inhibitory concentration of these three complexes was investigated in order to determine their in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium malmoense, and Mycobacterium kansasii. The MIC values were determined using the Microplate Alamar Blue Assay. The best MIC values found for the complexes were 9.75 mu M for Ag(l)-aspartame against M. kansasii and 15.7 mu M for Ag(I)-cyclamate against M. tuberculosis.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, Dept Ciências Biol, Araraquara, SP, Brazil
dc.description.affiliationInst Adolfo Lutz Registro, Lab Ribeirao Preto, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, Dept Ciências Biol, Araraquara, SP, Brazil
dc.format.extent538-542
dc.identifierhttp://dx.doi.org/10.1002/ardp.200700040
dc.identifier.citationArchiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 340, n. 10, p. 538-542, 2007.
dc.identifier.doi10.1002/ardp.200700040
dc.identifier.issn0365-6233
dc.identifier.urihttp://hdl.handle.net/11449/7633
dc.identifier.wosWOS:000250488600005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofArchiv Der Pharmazie
dc.relation.ispartofjcr2.288
dc.relation.ispartofsjr0,413
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectantimycobacterial activitypt
dc.subjectMABApt
dc.subjectsilver-aspartamept
dc.subjectsilver-cyclamatept
dc.subjectsilver-saccharinpt
dc.titleSynthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentQuímica Inorgânica - IQARpt

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Araraquara - IQAR - Instituto de Química
Araraquara - FCF - Faculdade de Ciências Farmacêuticas