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Detection of SPM and IMP metallo-beta-lactamases in clinical specimens of Pseudomonas aeruginosa from a Brazilian public tertiary hospital

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dc.contributor.authorCamargo, Carlos Henrique [UNESP]
dc.contributor.authorBruder-Nascimento, Ariane [UNESP]
dc.contributor.authorMondelli, Alessandro Lia [UNESP]
dc.contributor.authorMontelli, Augusto Cezar [UNESP]
dc.contributor.authorSadatsune, Terue [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:24Z
dc.date.available2014-05-20T13:33:24Z
dc.date.issued2011-09-01
dc.description.abstractPhenotypic and genotypic SPM and IMP metallo-beta-lactamases (MBL) detection and also the determination of minimal inhibitory concentrations (MIC) to imipenem, meropenem and ceftazidime were evaluated in 47 multidrug-resistant Pseudomonas aeruginosa isolates from clinical specimens. Polymerase chain reaction detected 14 positive samples to either bla(SPM) or bla(IMP) genes, while the best phenotypic assay (ceftazidime substrate and mercaptopropionic acid inhibitor) detected 13 of these samples. Imipenem, meropenem and ceftazidime MICs were higher for MBL positive compared to MBL negative isolates. We describe here the SPM and IMP MBL findings in clinical specimens of P. aeruginosa from the University Hospital of Botucatu Medical School, São Paulo, Brazil, that reinforce local studies showing the high spreading of bla(SPM) and bla(IMP) genes among Brazilian clinical isolates.en
dc.description.affiliationUniv Estatual Paulista UNESP, Botucatu, SP, Brazil
dc.description.affiliationUNESP, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estatual Paulista UNESP, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Botucatu, SP, Brazil
dc.format.extent478-481
dc.identifierhttp://dx.doi.org/10.1590/S1413-86702011000500011
dc.identifier.citationBrazilian Journal of Infectious Diseases. Salvador: Contexto, v. 15, n. 5, p. 478-481, 2011.
dc.identifier.fileS1413-86702011000500011-en.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702011000500011
dc.identifier.urihttp://hdl.handle.net/11449/11437
dc.identifier.wosWOS:000295936600011
dc.language.isoeng
dc.publisherContexto
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.relation.ispartofjcr2.083
dc.relation.ispartofsjr0,817
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPseudomonas aeruginosaen
dc.subjectdrug resistanceen
dc.subjectbacterialen
dc.subjectcarbapenemsen
dc.subjectmetalloproteinsen
dc.subjectpolymerase chain reactionen
dc.titleDetection of SPM and IMP metallo-beta-lactamases in clinical specimens of Pseudomonas aeruginosa from a Brazilian public tertiary hospitalen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjid/iaboutj.htm
dcterms.rightsHolderContexto
dspace.entity.typePublication
unesp.author.lattes7697507273984482[3]
unesp.author.orcid0000-0001-6834-0085[1]
unesp.author.orcid0000-0002-4401-5656[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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Botucatu - FMB - Faculdade de Medicina
Botucatu - IBB - Instituto de Biociências