Logotipo do repositório
 

Publicação:
Interaction between arginine vasopressin and angiotensin II receptors in the central regulation of sodium balance

dc.contributor.authorSaad, W. A.
dc.contributor.authorCamargo, LAD
dc.contributor.authorAntunes-Rodrigues, J.
dc.contributor.authorGuarda, IFMS
dc.contributor.authorGuarda, R. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNITAU
dc.contributor.institutionUNIARA
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPubl Hosp State São Paulo
dc.date.accessioned2014-05-20T13:45:39Z
dc.date.available2014-05-20T13:45:39Z
dc.date.issued2005-12-15
dc.description.abstractWe speculated that the influence of lateral preoptic area (LPO) in sodium balance, involves arginine(8)-vasopressin (AVP) and angiotensin (ANG II) on Na+ uptake in LPO. Therefore, the present study investigated the effects of central administration of specific AVP and ANG 11 antagonists (d(CH2)(5)-Tyr (Me)-AVP (AAVP) and [Adamanteanacetyl(1), 0-ET-D-Tyr(2), Val(4), Aminobutyryl(6), Arg(8.9)]-AVP (ATAVP) antagonists of V-1 and V-2 receptors of AVP. Also the effects of losartan and CGP42112A (selective ligands of the AT(1) and AT(2) angiotensin receptors, respectively), was investigated on Na+ uptake and renal fluid and electrolyte excretion. After an acclimatization period of 7 days, the animals were maintained under tribromoethanol (200 mg/kg body weight, intraperitonial) anesthesia and placed in a Kopf stereotaxic instrument. Stainless guide cannula was implanted into the LPO. AAVP and ATAVP injected into the LPO prior to AVP produced a reduction in the NaCl intake. Both the AT(1) and AT(2) ligands administered into the LPO elicited a decrease in the NaCl intake induced by AVP injected into the LPO. AVP injection into the LPO increased sodium renal excretion, but this was reduced by prior AAVP administration. The ATAVP produced a decreased in the natriuretic effect of AVP. The losartan injected into LPO previous to AVP decreased the sodium excretion and the CGP 421122A also decreased the natriuretic effect of AVP. The AVP produced an antidiuresis effect that was inhibited by prior administration into LPO of the ATAVP. The AAVP produced no change in the antidiuretic effect of AVP. These results suggest that LPO are implicated in sodium balance that is mediated by V-1, V-2, AT(2) and AT(2) receptors. (c) 2005 Elsevier B.V All rights reserved.en
dc.description.affiliationUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUNITAU, Basic Inst Biosci, Taubate, SP, Brazil
dc.description.affiliationUNIARA, Dept Nat & Exact Sci, Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Physiol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Clin Hosp, BR-05508 São Paulo, Brazil
dc.description.affiliationPubl Hosp State São Paulo, Dept Anesthesiol, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.format.extent53-58
dc.identifierhttp://dx.doi.org/10.1016/j.regpep.2005.09.003
dc.identifier.citationRegulatory Peptides. Amsterdam: Elsevier B.V., v. 132, n. 1-3, p. 53-58, 2005.
dc.identifier.doi10.1016/j.regpep.2005.09.003
dc.identifier.issn0167-0115
dc.identifier.urihttp://hdl.handle.net/11449/16069
dc.identifier.wosWOS:000233711500009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRegulatory Peptides
dc.relation.ispartofsjr0,512
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectvasopressinpt
dc.subjectangiotensin receptor subtypespt
dc.subjectsodium balancept
dc.subjectlateral preoptic areapt
dc.titleInteraction between arginine vasopressin and angiotensin II receptors in the central regulation of sodium balanceen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublicationb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isDepartmentOfPublication.latestForDiscoveryb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

Arquivos

Licença do Pacote

Agora exibindo 1 - 1 de 1
Carregando...
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: