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Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosis

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dc.contributor.authordos Santos, Paulo Victor P.
dc.contributor.authorRibeiro, Camila M. [UNESP]
dc.contributor.authorPavan, Fernando R. [UNESP]
dc.contributor.authorCorbi, Pedro P.
dc.contributor.authorBergamini, Fernando R.G.
dc.contributor.authorCarvalho, Marcos A.
dc.contributor.authorD'Oliveria, Kaique A.
dc.contributor.authorCuin, Alexandre
dc.contributor.institutionFederal University of Juiz de Fora – UFJF
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionFederal University of Mato Grosso – UFMT
dc.date.accessioned2021-06-25T11:12:49Z
dc.date.available2021-06-25T11:12:49Z
dc.date.issued2021-06-15
dc.description.abstractIn the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 µg/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis.en
dc.description.affiliationLQBin – Laboratory of BioInorganic Chemistry Chemistry Department Institute of Exact Sciences Federal University of Juiz de Fora – UFJF
dc.description.affiliationSão Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory Araraquara
dc.description.affiliationInstitute of Chemistry University of Campinas – UNICAMP
dc.description.affiliationLaboratory of Synthesis of Bioinspired Molecules Institute of Chemistry Federal University of Uberlândia – UFU
dc.description.affiliationChemistry Department Federal University of Mato Grosso – UFMT
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory Araraquara
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdFAPEMIG: 2018
dc.identifierhttp://dx.doi.org/10.1016/j.molstruc.2021.130193
dc.identifier.citationJournal of Molecular Structure, v. 1234.
dc.identifier.doi10.1016/j.molstruc.2021.130193
dc.identifier.issn0022-2860
dc.identifier.scopus2-s2.0-85102039591
dc.identifier.urihttp://hdl.handle.net/11449/208478
dc.language.isoeng
dc.relation.ispartofJournal of Molecular Structure
dc.sourceScopus
dc.subjectMycobacterium tuberculosis
dc.subjectN-acylhydrazones
dc.subjectPowder X-ray diffraction
dc.subjectSilver complexes
dc.titlePromising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and isoniazid against multidrug resistance in tuberculosisen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublication5004bcab-94af-4939-b980-091ae9d0a19e
relation.isDepartmentOfPublication.latestForDiscovery5004bcab-94af-4939-b980-091ae9d0a19e
unesp.author.orcid0000-0001-6402-7147[2]
unesp.author.orcid0000-0002-8357-3044 0000-0002-8357-3044[5]
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas