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The human papillomavirus (HPV)-related cancer biology: An overview

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dc.contributor.authorAraldi, Rodrigo Pinheiro
dc.contributor.authorSant'Ana, Thalita Araujo
dc.contributor.authorMódolo, Diego Grando
dc.contributor.authorde Melo, Thatiana Correa
dc.contributor.authorSpadacci-Morena, Diva Denelle
dc.contributor.authorde Cassia Stocco, Rita
dc.contributor.authorCerutti, Janete Maria
dc.contributor.authorde Souza, Edislane Barreiros [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionButantan Institute
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:54:36Z
dc.date.available2018-12-11T16:54:36Z
dc.date.issued2018-10-01
dc.description.abstractDespite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20–25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agent-related cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies.en
dc.description.affiliationGenetics Basis of Thyroid Cancer Laboratory São Paulo FederalUniversity (UNIFESP)
dc.description.affiliationGenetics Laboratory Butantan Institute
dc.description.affiliationHaematology and Molecular Biology Laboratory Medical School University of São Paulo (USP)
dc.description.affiliationPathophysiology Laboratory Butantan Institute
dc.description.affiliationGenetics Laboratory Biotechnology Department Faculty of Science and Languages São Paulo State University (UNESP)
dc.description.affiliationUnespGenetics Laboratory Biotechnology Department Faculty of Science and Languages São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/20617-5
dc.description.sponsorshipIdFAPESP: 2017/14948-7
dc.format.extent1537-1556
dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2018.06.149
dc.identifier.citationBiomedicine and Pharmacotherapy, v. 106, p. 1537-1556.
dc.identifier.doi10.1016/j.biopha.2018.06.149
dc.identifier.file2-s2.0-85050402559.pdf
dc.identifier.file2-s2.0-85050402559
dc.identifier.issn1950-6007
dc.identifier.issn0753-3322
dc.identifier.scopus2-s2.0-85050402559
dc.identifier.urihttp://hdl.handle.net/11449/171253
dc.language.isoeng
dc.relation.ispartofBiomedicine and Pharmacotherapy
dc.relation.ispartofsjr0,951
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCancer progression
dc.subjectHPV
dc.subjectMetastasis
dc.subjectMutation
dc.subjectOncology
dc.titleThe human papillomavirus (HPV)-related cancer biology: An overviewen
dc.typeResenha
dspace.entity.typePublication

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