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Publicação:
Effects of diabetes mellitus on dental pulp: A systematic review of in vivo and in vitro studies

dc.contributor.authorPimenta, Rafaella Milla Nunes
dc.contributor.authordos Reis-Prado, Alexandre Henrique
dc.contributor.authorde Castro Oliveira, Sabrina
dc.contributor.authorGoto, Juliana [UNESP]
dc.contributor.authorCosme-Silva, Leopoldo
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.authorBenetti, Francine
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Alagoas (UFAL)
dc.date.accessioned2023-03-02T05:21:44Z
dc.date.available2023-03-02T05:21:44Z
dc.date.issued2022-01-01
dc.description.abstractObjectives: This systematic review (PROSPERO CRD42021227711) evaluated the influence of diabetes mellitus (DM) on the response of the pulp tissue and in the pulp cells behaviour. Materials and Methods: Searches in PubMed/MEDLINE, Embase, Web of Science and OpenGrey were performed until March 2022. Studies evaluating the effects of DM in the pulp tissue inflammation and in the cell behaviour were included, followed by risk of bias assessment (Methodological Index for Non-Randomized Studies and SYRCLE's RoB tools). The meta-analysis was unfeasible, and a narrative synthesis for each outcome was provided. Results: Of the 615 studies, 21 were eligible, mainly with in vivo analysis (16 studies). The pulp inflammation (10 studies) was analysed mainly by haematoxylin–eosin stain; DM increased pulp inflammation/degeneration in 9 studies, especially after dental procedures. The cell viability (5 studies) was analysed mostly using MTT assay; DM and glycating agents decreased cellular viability in 3 studies. DM reduced collagen in all of three studies. There were controversial results regarding mineralization; however, increased alkaline phosphatase was reported in three of four studies. Conclusions: DM seems to increase inflammation/degeneration and mineralization in the pulp tissue while reducing cell proliferation. Further analyses in human pulp are important to provide stronger evidence.en
dc.description.affiliationDepartment of Restorative Dentistry School of Dentistry Universidade Federal de Minas Gerais (UFMG)
dc.description.affiliationDepartment of Restorative Dentistry School of Dentistry São Paulo State University (Unesp)
dc.description.affiliationDepartment of Restorative Dentistry School of Dentistry Federal University of Alagoas (UFAL)
dc.description.affiliationUnespDepartment of Restorative Dentistry School of Dentistry São Paulo State University (Unesp)
dc.identifierhttp://dx.doi.org/10.1111/odi.14267
dc.identifier.citationOral Diseases.
dc.identifier.doi10.1111/odi.14267
dc.identifier.issn1601-0825
dc.identifier.issn1354-523X
dc.identifier.scopus2-s2.0-85132434585
dc.identifier.urihttp://hdl.handle.net/11449/241959
dc.language.isoeng
dc.relation.ispartofOral Diseases
dc.sourceScopus
dc.subjectdiabetes mellitus
dc.subjecthyperglycaemia
dc.subjectinflammation
dc.subjectinsulin resistance
dc.subjectpulp tissue
dc.subjectsystematic review
dc.titleEffects of diabetes mellitus on dental pulp: A systematic review of in vivo and in vitro studiesen
dc.typeResenhapt
dspace.entity.typePublication
relation.isOrgUnitOfPublication8b3335a4-1163-438a-a0e2-921a46e0380d
relation.isOrgUnitOfPublication.latestForDiscovery8b3335a4-1163-438a-a0e2-921a46e0380d
unesp.author.orcid0000-0001-7479-3443[1]
unesp.author.orcid0000-0002-5866-7137[2]
unesp.author.orcid0000-0003-2659-8322[3]
unesp.author.orcid0000-0002-6040-3560[4]
unesp.author.orcid0000-0002-5755-1933[5]
unesp.author.orcid0000-0003-2348-7846[6]
unesp.author.orcid0000-0002-5459-353X[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentOdontologia Restauradora - FOApt

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