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Myeloperoxidase is not a good biomarker for preeclampsia prediction

dc.contributor.authorRocha-Penha, L. [UNESP]
dc.contributor.authorBettiol, H.
dc.contributor.authorBarbieri, M. A.
dc.contributor.authorCardoso, V. C.
dc.contributor.authorCavalli, R. C.
dc.contributor.authorSandrim, V. C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:14:28Z
dc.date.available2018-12-11T17:14:28Z
dc.date.issued2017-12-01
dc.description.abstractMyeloperoxidase is a proinflammatory enzyme found to be increased in patients with established preeclampsia but never investigated before the disease onset. Here we examined myeloperoxidase concentration and activity in plasma and urine samples from pregnant women who remained normotensive throughout pregnancy and those who developed preeclampsia in order to assess its potential to predict this disorder. Our sample consisted of 30 cases who developed preeclampsia (14 severe and 16 mild) and 57 controls who remained healthy throughout pregnancy, derived from the Brazilian Ribeirão Preto and São Luís prenatal cohort (BRISA). Myeloperoxidase concentration were assessed using a commercial ELISA kit and enzymatic activity through tetramethylbenzidine oxidation. No statistical differences were found in myeloperoxidase levels nor activity between plasma or urine samples from controls, severe and mild cases. Myeloperoxidase did not seem to have a potential application for preeclampsia prediction.en
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)
dc.description.affiliationOf Pediatrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo
dc.description.affiliationDepartment of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)
dc.identifierhttp://dx.doi.org/10.1038/s41598-017-09272-4
dc.identifier.citationScientific Reports, v. 7, n. 1, 2017.
dc.identifier.doi10.1038/s41598-017-09272-4
dc.identifier.file2-s2.0-85028687490.pdf
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85028687490
dc.identifier.urihttp://hdl.handle.net/11449/175122
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.relation.ispartofsjr1,533
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.titleMyeloperoxidase is not a good biomarker for preeclampsia predictionen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationab63624f-c491-4ac7-bd2c-767f17ac838d
relation.isOrgUnitOfPublication.latestForDiscoveryab63624f-c491-4ac7-bd2c-767f17ac838d
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt

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