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Toxicity of ad lib. overfeeding: effects on cardiac tissue

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dc.contributor.authorFaine, L. A.
dc.contributor.authorDiniz, Y. S.
dc.contributor.authorAlmeida, J. A.
dc.contributor.authorNovelli, ELB
dc.contributor.authorRibas, B. O.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Salud Carlos III
dc.date.accessioned2014-05-20T15:25:58Z
dc.date.available2014-05-20T15:25:58Z
dc.date.issued2002-05-01
dc.description.abstractThe aim of the present study was to determine the effects of ad lib, overfeeding and of dietary restriction (DR) on oxidative stress in cardiac tissue. Lipoperoxide concentrations ere decreased and antioxidant enzymes ere increased in moderate-DR-fed rats. Severe-DR induced increased lipoperoxide concentrations. Overfeeding increased lipoperoxide levels in cardiac tissue. Total superoxide dismutase (SOD) and Cu-Zn superoxide dismutase (Cu-Zn SOD) activities were decreased in cardiac tissue at 35 days of overfeeding. As no changes in glutathione peroxidase (GSH-Px) ere observed in overfed rats, awhile SOD and Cu-Zn SOD activities were decreased in these animals. it is assumed that superoxide anion is an important intermediate in the toxicity of ad lib, overfeeding. Overfeeding induced alterations in markers of oxidative stress in cardiac tissue. (C) 2002 Elsevier B.V. Ltd. All rights reserved.en
dc.description.affiliationUNESP, Inst Biociencias, Dept Chem & Biochem, São Paulo, Brazil
dc.description.affiliationUNESP, Fac Med, São Paulo, Brazil
dc.description.affiliationInst Salud Carlos III, Natl Ctr Environm Hlth, Dept Toxicol, Madrid, Spain
dc.description.affiliationUnespUNESP, Inst Biociencias, Dept Chem & Biochem, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Med, São Paulo, Brazil
dc.format.extent663-668
dc.identifierhttp://dx.doi.org/10.1016/S0278-6915(02)00004-2
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 40, n. 5, p. 663-668, 2002.
dc.identifier.doi10.1016/S0278-6915(02)00004-2
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/11449/36273
dc.identifier.wosWOS:000175672500011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectratpt
dc.subjectreactive oxygen speciespt
dc.subjectoverfeedingpt
dc.subjectdietary restrictionpt
dc.subjectheartpt
dc.titleToxicity of ad lib. overfeeding: effects on cardiac tissueen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication

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