Publicação:
Efficacy and safety of itraconazole pulse therapy: Brazilian multicentric study on toenail onychomycosis caused by dermatophytes

dc.contributor.authorRamos-e-Silva, M.
dc.contributor.authorMarques, Silvio Alencar [UNESP]
dc.contributor.authorGontijo, B.
dc.contributor.authorZaitz, C.
dc.contributor.authorCampbell, I
dc.contributor.authorVeloso, S. T.
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionSanta Casa Misericordia São Paulo
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.date.accessioned2014-05-20T15:24:18Z
dc.date.available2014-05-20T15:24:18Z
dc.date.issued1998-09-01
dc.description.abstractBackground Itraconazole is a large spectrum triazole with known efficacy in both continuous and pulse therapy for various mycoses.Objectives Evaluate the efficacy and tolerability of itraconazole pulse therapy for onychomycosis of the toenails due to dermatophytes, in a prospective, open, non-comparative and multicentric investigation.Patients and methods the trial was completed by 72 patients of an initial total of 89. Treatment consisted of four cycles of itraconazole, 200 mg twice a day, for seven consecutive days each month. Patients were evaluated clinically, mycologically and biochemically before, during and at the end of the investigation, and were divided into two groups according to the measure of normal portion of the most affected nail (target nail), as follows: Group 1. 0-5.9 mm; and Group 2: more than 6 mm.Results Improvement was satisfactory and progressive. Results were statistically significant, when comparing the three moments of the study: pre-treatment, end of therapy (fourth month) and follow-up (ninth month) in both groups.Conclusions Itraconazole pulse therapy was efficient and safe for the treatment of onychomycosis caused by dermatophytes, although a much higher daily dosage than the known continuous administration was used. Group 1, with nails initially more extensively affected, had a more evident improvement, by the mean variation in millimeters of normal portion of the target nail. This group showed a very satisfactory response, although not reaching total cure, thus demonstrating the great importance of early treatment of this disease. A residual therapeutic effect is maintained even after suspension of the drug. Group 2 obtained better total cure rates, and four pulses were, in general, sufficient, whereas more cycles would have been beneficial for the Group 1 patients with more extensive involvement. (C) 1998 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationUniv Fed Rio de Janeiro Hosp, Rio de Janeiro, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Belo Horizonte, MG, Brazil
dc.description.affiliationSanta Casa Misericordia São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Brasilia, Brasilia, DF, Brazil
dc.description.affiliationUniv Rio de Janeiro, Rio de Janeiro, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu, SP, Brazil
dc.format.extent109-116
dc.identifierhttp://dx.doi.org/10.1016/S0926-9959(98)00048-8
dc.identifier.citationJournal of the European Academy of Dermatology and Venereology. Amsterdam: Elsevier B.V., v. 11, n. 2, p. 109-116, 1998.
dc.identifier.doi10.1016/S0926-9959(98)00048-8
dc.identifier.issn0926-9959
dc.identifier.lattes8789480458377552
dc.identifier.urihttp://hdl.handle.net/11449/34937
dc.identifier.wosWOS:000076412700002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of the European Academy of Dermatology and Venereology
dc.relation.ispartofjcr4.287
dc.relation.ispartofsjr1,831
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdermatophytespt
dc.subjectitraconazolept
dc.subjectonychomycosispt
dc.subjectpulse therapypt
dc.subjecttherapypt
dc.titleEfficacy and safety of itraconazole pulse therapy: Brazilian multicentric study on toenail onychomycosis caused by dermatophytesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes8789480458377552
unesp.author.orcid0000-0003-1625-0760[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDermatologia e Radioterapia - FMBpt

Arquivos

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: