Lipid peroxidation and antioxidant capacity of G6PD-deficient patients with A-(202G>A) mutation
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Undergraduate course
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Genetics and Molecular Research
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Article
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Acesso aberto
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Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy in which reduced NADPH concentrations are not maintained, resulting in oxidative damage. We evaluated G6PD activity, oxidative stress levels and Trolox equivalent antioxidant capacity in individuals with the A-(202G>A) mutation for G6PD deficiency. Five hundred and forty-four peripheral blood samples were screened for G6PD deficiency; we also analyzed lipid peroxidation products measured as thiobarbituric acid reactive species and Trolox equivalent antioxidant capacity. Men with the A-(202G>A) mutation had lower G6PD activity than women with the same mutation. Individuals with the A-(202G>A) mutation also differed in mean Trolox equivalent antioxidant capacity values but not for thiobarbituric acid reactive species values. We concluded that A-(202G>A) mutation is associated with reduced G6PD activity and increased Trolox equivalent antioxidant capacity. ©FUNPEC-RP.
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Keywords
G6PD deficiency Oxidative stress TBARS TEAC glucose 6 phosphate dehydrogenase thiobarbituric acid reactive substance trolox C adolescent adult aged antioxidant activity blood sampling colorimetry controlled study female gene mutation glucose 6 phosphate dehydrogenase deficiency human lipid peroxidation major clinical study male oxidative stress sex difference trolox equivalent antioxidant capacity Adolescent Adult Aged Aged, 80 and over Antioxidants Base Sequence DNA Primers Female Glucosephosphate Dehydrogenase Deficiency Humans Lipid Peroxidation Male Middle Aged Mutation Young Adult
Language
English
Citation
Genetics and Molecular Research, v. 8, n. 4, p. 1345-1351, 2009.
