Publicação:
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress

Carregando...
Imagem de Miniatura

Data

2011-12-20

Orientador

Coorientador

Pós-graduação

Curso de graduação

Título da Revista

ISSN da Revista

Título de Volume

Editor

Biomed Central Ltd.

Tipo

Artigo

Direito de acesso

Acesso abertoAcesso Aberto

Resumo

Background: Exercise stress was shown to increase oxidative stress in rats. It lacks reports of increased protection afforded by dietary antioxidant supplements against ROS production during exercise stress. We evaluated the effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress.Methods: Wistar rats were divided into three groups: 1) control group; 2) exercise stress group and; 3) exercise stress + Vitamin E group. Rats from the group 3 were treated with gavage administration of 1 mL of Vitamin E (5 mg/kg) for seven consecutive days. Animals from groups 2 and 3 were submitted to a bout of swimming exhaustive exercise stress. Kidney samples were analyzed for Thiobarbituric Acid Reactive Substances to (TBARS) by malondialdehyde (MDA), reduced glutathione (GSH) and vitamin-E levels.Results: The group treated with vitamin E and submitted to exercise stress presented the lowest levels of renal MDA (1: 0.16+0.02 mmmol/mgprot vs. 2: 0.34+0.07 mmmol/mgprot vs. 3: 0.1+0.01 mmmol/mgprot; p < 0.0001), the highest levels of renal GSH (1: 23+4 mu mol/gprot vs. 2: 23+2 mu mol/gprot vs. 3: 58+9 mu mol/gprot; p < 0.0001) and the highest levels of renal vitamin E (1: 24+6 mu M/gtissue vs. 2: 28+2 mu M/gtissue vs. 3: 43+4 mu M/gtissue; p < 0.001).Conclusion: Vitamin E supplementation improved non-enzymatic antioxidant activity in young rats submitted to exhaustive exercise stress.

Descrição

Palavras-chave

Idioma

Inglês

Como citar

Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 11, p. 6, 2011.

Itens relacionados

Unidades

Departamentos

Cursos de graduação

Programas de pós-graduação