Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production
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Springer Nature
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Resumo
The effects of isolated compounds from Brazilian lichens and their derivatives on H 2O 2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H 2O 2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H 2O 2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.
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Palavras-chave
Hydrogen peroxide , Lichens , Macrophages , Nitric oxide , Phenolic compounds , 8' o n propyl norstitic acid , 9' o ethyl norstitic acid , 9' o ethyl protocetraric acid , 9' o iso propyl protocetraric acid , 9' o methyl protocetraric acid , 9' o n butyl protocetraric acid , 9' o n hexyl protocetraric acid , 9' o n pentyl protocetraric acid , 9' o n propyl protocetraric acid , 9' o sec butyl protocetraric acid , 9' o terc butyl protocetraric acid , comprotocetraric acid , hydrogen peroxide , immunostimulating agent , lichexanthone , methyl protocetrate , nitric oxide , nitroblue tetrazolium , norstitic acid , phenol derivative , physodic acid , protocetraric acid , unclassified drug , animal cell , cell stimulation , cell viability , cytotoxicity , drug determination , drug structure , drug synthesis , immune response , immunomodulation , lichen , macrophage , mouse , nonhuman , peritoneum , structure activity relation , supernatant , Swiss Webster mouse
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Inglês
Citação
Brazilian Journal of Pharmacognosy, v. 19, n. 4, p. 847-852, 2009.
