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Cyclin D1 expression in penile cancer

dc.contributor.authorEverton Duarte, Wesliany
dc.contributor.authorDiniz Pinho, Jaqueline
dc.contributor.authorda Costa Melo, Syomara Pereira
dc.contributor.authorRodrigo Diniz Duarte, Denner
dc.contributor.authorda Guia Ribeiro do Carmo, Juliana Martins
dc.contributor.authorSalim Khayat, André
dc.contributor.authorRibamar Rodrigues Calixto, José
dc.contributor.authorAdriano Garcia Campos, Marcos [UNESP]
dc.contributor.authorda Graça Carvalhal Frazão Correa, Rita
dc.contributor.authorMachado Alencar Júnior, Antonio
dc.contributor.authorAugusto Lima Teixeira-Júnior, Antônio
dc.contributor.authorEanes Barros Silva, Gyl
dc.contributor.institutionFederal University of Maranhão
dc.contributor.institutionUniversity Hospital of the Federal University of Maranhão
dc.contributor.institutionState University of Maranhão
dc.contributor.institutionUniversidade Federal do Pará (UFPA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2025-04-29T19:14:24Z
dc.date.issued2024-01-01
dc.description.abstractThe main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017. A review of clinical, epidemiological, and histopathological data was performed, Human Papillomavírus (HPV) DNA was detected using polymerase chain reaction (PCR) and cyclin D1 expression analysis was performed using immunohistochemical techniques. The data revealed that the absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes (p = 0.001), while its expression was associated with high-grade tumors (p = 0.014), histological subtype (p = 0.001), presence of sarcomatoid transformation (p = 0.04), and perineural invasion (p = 0.023). Patients with cyclin D1 expression exhibited lower disease-free survival compared to the cyclin D1-negative group, although the difference was not statistically significant. The results suggest that cyclin D1 may be a potential biomarker for PC, especially for poorer prognosis.en
dc.description.affiliationPostgraduate Program in Adult Health Federal University of Maranhão
dc.description.affiliationClinical Research Center University Hospital of the Federal University of Maranhão
dc.description.affiliationState University of Maranhão
dc.description.affiliationUniversity Hospital Federal University of Maranhão
dc.description.affiliationOncology Research Center Federal University of Pará
dc.description.affiliationClinical Hospital of Medical School São Paulo State University, Unesp, Botucatu
dc.description.affiliationPostgraduate Program in Nursing Federal University of Maranhão
dc.description.affiliationPostgraduate Program in Health Science Federal University of Maranhão
dc.description.affiliationDepartment of Genetics and Postgraduate Program in Genetics Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationDepartment of Pathology Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationUnespClinical Hospital of Medical School São Paulo State University, Unesp, Botucatu
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCAPES: 01339/17
dc.description.sponsorshipIdCAPES: 713 01184/19
dc.format.extent302-311
dc.identifierhttp://dx.doi.org/10.18632/oncotarget.28584
dc.identifier.citationOncotarget, v. 15, p. 302-311.
dc.identifier.doi10.18632/oncotarget.28584
dc.identifier.issn1949-2553
dc.identifier.scopus2-s2.0-85193205764
dc.identifier.urihttps://hdl.handle.net/11449/302373
dc.language.isoeng
dc.relation.ispartofOncotarget
dc.sourceScopus
dc.subjectbiomarkers
dc.subjectcyclin D1
dc.subjectimmunohistochemistry
dc.subjectpenile neoplasms
dc.titleCyclin D1 expression in penile canceren
dc.typeArtigopt
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt

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