Cyclin D1 expression in penile cancer
dc.contributor.author | Everton Duarte, Wesliany | |
dc.contributor.author | Diniz Pinho, Jaqueline | |
dc.contributor.author | da Costa Melo, Syomara Pereira | |
dc.contributor.author | Rodrigo Diniz Duarte, Denner | |
dc.contributor.author | da Guia Ribeiro do Carmo, Juliana Martins | |
dc.contributor.author | Salim Khayat, André | |
dc.contributor.author | Ribamar Rodrigues Calixto, José | |
dc.contributor.author | Adriano Garcia Campos, Marcos [UNESP] | |
dc.contributor.author | da Graça Carvalhal Frazão Correa, Rita | |
dc.contributor.author | Machado Alencar Júnior, Antonio | |
dc.contributor.author | Augusto Lima Teixeira-Júnior, Antônio | |
dc.contributor.author | Eanes Barros Silva, Gyl | |
dc.contributor.institution | Federal University of Maranhão | |
dc.contributor.institution | University Hospital of the Federal University of Maranhão | |
dc.contributor.institution | State University of Maranhão | |
dc.contributor.institution | Universidade Federal do Pará (UFPA) | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2025-04-29T19:14:24Z | |
dc.date.issued | 2024-01-01 | |
dc.description.abstract | The main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017. A review of clinical, epidemiological, and histopathological data was performed, Human Papillomavírus (HPV) DNA was detected using polymerase chain reaction (PCR) and cyclin D1 expression analysis was performed using immunohistochemical techniques. The data revealed that the absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes (p = 0.001), while its expression was associated with high-grade tumors (p = 0.014), histological subtype (p = 0.001), presence of sarcomatoid transformation (p = 0.04), and perineural invasion (p = 0.023). Patients with cyclin D1 expression exhibited lower disease-free survival compared to the cyclin D1-negative group, although the difference was not statistically significant. The results suggest that cyclin D1 may be a potential biomarker for PC, especially for poorer prognosis. | en |
dc.description.affiliation | Postgraduate Program in Adult Health Federal University of Maranhão | |
dc.description.affiliation | Clinical Research Center University Hospital of the Federal University of Maranhão | |
dc.description.affiliation | State University of Maranhão | |
dc.description.affiliation | University Hospital Federal University of Maranhão | |
dc.description.affiliation | Oncology Research Center Federal University of Pará | |
dc.description.affiliation | Clinical Hospital of Medical School São Paulo State University, Unesp, Botucatu | |
dc.description.affiliation | Postgraduate Program in Nursing Federal University of Maranhão | |
dc.description.affiliation | Postgraduate Program in Health Science Federal University of Maranhão | |
dc.description.affiliation | Department of Genetics and Postgraduate Program in Genetics Ribeirão Preto Medical School University of São Paulo | |
dc.description.affiliation | Department of Pathology Ribeirão Preto Medical School University of São Paulo | |
dc.description.affiliationUnesp | Clinical Hospital of Medical School São Paulo State University, Unesp, Botucatu | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | CAPES: 01339/17 | |
dc.description.sponsorshipId | CAPES: 713 01184/19 | |
dc.format.extent | 302-311 | |
dc.identifier | http://dx.doi.org/10.18632/oncotarget.28584 | |
dc.identifier.citation | Oncotarget, v. 15, p. 302-311. | |
dc.identifier.doi | 10.18632/oncotarget.28584 | |
dc.identifier.issn | 1949-2553 | |
dc.identifier.scopus | 2-s2.0-85193205764 | |
dc.identifier.uri | https://hdl.handle.net/11449/302373 | |
dc.language.iso | eng | |
dc.relation.ispartof | Oncotarget | |
dc.source | Scopus | |
dc.subject | biomarkers | |
dc.subject | cyclin D1 | |
dc.subject | immunohistochemistry | |
dc.subject | penile neoplasms | |
dc.title | Cyclin D1 expression in penile cancer | en |
dc.type | Artigo | pt |
dspace.entity.type | Publication | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatu | pt |