Profile of Maytenus aquifolium action over free radicals and reactive oxygen species
Carregando...
Fontes externas
Fontes externas
Data
Autores
Vellosa, José Carlos Rebuglio 
Barbosa, Vanessa de Frias
Khalil, Najeh Maissar
De Aparecida Freitas Formenton Dos Santos Macedo, Vânia
Furlan, Maysa
Brunetti, Iguatemy Lourenço
Mascarenhas de Faria Oliveira, Olga Maria
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
FapUNIFESP (SciELO)
Tipo
Artigo
Direito de acesso
Acesso aberto
Fontes externas
Fontes externas
Resumo
Reactive oxygen species (ROS) and free radical species have been implicated in initiating, accompanying or causing many diseases in living organisms; there is thus, a continual need for antioxidants molecules to inactivate ROS/free radicals. Many studies of plants crude extracts have demonstrated free-radical scavenging and antioxidant action. Maytenus species have long been used, in several countries, as traditional medicines against gastric ulcers, dyspepsia and others gastric problems and for their anti-inflammatory properties. In this study, Maytenus aquifolium (Celastraceae) root bark ethanol extract was assessed for its ability to scavenge free radicals and reactive oxygen species. The results were expressed as percentage inhibition of the active species. The extract was efficient against studied reactive species: DPPH radical (obtained inhibition = 35.5 ± 1.3 %), ABTS.+ (IC50 = 0.0036 ± 0.0003 mg/mL), HOCl (IC50 = 0.002 ± 0.0001 mg/mL), O2 .- (obtained inhibition = 36.0 ± 2.1 %), and NO. (obtained inhibition = 18.3 ± 0.4 %). Uniterms Oxidant species Free radicals Maytenus aquifolium Oxidative damage.
Descrição
Palavras-chave
1,1 diphenyl 2 picrylhydrazyl , 2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid) , alcohol , benzothiazoline derivative , free radical , hypochlorous acid , Maytenus aquifolium extract , nitric oxide , plant medicinal product , reactive oxygen metabolite , scavenger , antiinflammatory activity , antioxidant activity , bark , dyspepsia , Maytenus , medicinal plant , plant root , stomach ulcer , traditional medicine
Idioma
Inglês
Citação
Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences, v. 43, n. 3, p. 447-453, 2007.
