Publication: Nickel chloride effects on erythrocyte generation of superoxide radical.
Loading...
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Type
Article
Access right
Abstract
The superoxide anion (O2-) is an extremely potent free radical which is produced during the metabolism of aerobic living cells. (O2-) may be involved in lipid peroxidation reactions which occur in a variety of systems. Cu-Zn superoxide dismutase, a metalloprotein, catalyzes the dismutation of the superoxide free radical and protects cells against superoxide damage. The ability of NiCl2 to prevent lysis of erythrocytes was tested in rats. NiCl2 administered by intratracheal route prevented hemolysis and decreased total lipids, phospholipids and bilirubin in serum. The protective effect of NiCl2 was linked to an increase in the erythrocyte activity of superoxide dismutase.
Description
Keywords
Language
English
Citation
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 23, n. 8, p. 643-645, 1990.
