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Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine

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dc.contributor.authorMenezes, CMS
dc.contributor.authorKirchgatter, K.
dc.contributor.authorDi Santi, SMF
dc.contributor.authorSavalli, C.
dc.contributor.authorMonteiro, F. G.
dc.contributor.authorPaula, G. A.
dc.contributor.authorFerreira, E. I.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSuperintendencia Controle Endemias
dc.date.accessioned2014-05-20T15:25:28Z
dc.date.available2014-05-20T15:25:28Z
dc.date.issued1997-11-01
dc.description.abstractBased on previous studies in vitro of the modulating effect of desipramine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the parasite was investigated. Both drugs in therapeutic doses showed an unexpected antimalarial effect in vitro in duplicate tests (IC50=44.26 and 46.53 mu g/L for desipramine, and 83.93 and 41.26 mu g/L for imipramine), but no reversal of resistance when added to cultures together with chloroquine.en
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, BR-05389970 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Ciências Saude, São Paulo, Brazil
dc.description.affiliationSuperintendencia Controle Endemias, Div Programas Especiais, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Matemat & Estatist, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Ciências Saude, São Paulo, Brazil
dc.format.extent697-700
dc.identifierhttp://dx.doi.org/10.1016/S0035-9203(97)90529-0
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. London: Royal Soc Tropical Medicine, v. 91, n. 6, p. 697-700, 1997.
dc.identifier.doi10.1016/S0035-9203(97)90529-0
dc.identifier.issn0035-9203
dc.identifier.urihttp://hdl.handle.net/11449/35893
dc.identifier.wosWOS:000071357700021
dc.language.isoeng
dc.publisherRoyal Soc Tropical Medicine
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.relation.ispartofjcr2.820
dc.relation.ispartofsjr1,174
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmalariapt
dc.subjectPlasmodium falciparumpt
dc.subjectchemotherapypt
dc.subjectdrug resistancept
dc.subjectchloroquinept
dc.subjectdesipraminept
dc.subjectimipraminept
dc.titleAntimalarial effect in vitro and lack of modulating effect of desipramine and imipramineen
dc.typeArtigo
dcterms.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dcterms.rightsHolderRoyal Soc Tropical Medicine
dspace.entity.typePublication
unesp.author.orcid0000-0002-2449-2316[2]

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