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A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models

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dc.contributor.authorSá, Nívea P.
dc.contributor.authorLima, Caroline M
dc.contributor.authorA Dos Santos, Julliana R.
dc.contributor.authorCosta, Marliete C.
dc.contributor.authorDe Barros, Patrícia P.
dc.contributor.authorJunqueira, Juliana C.
dc.contributor.authorVaz, Jéssica A.
dc.contributor.authorOliveira, Renata B.
dc.contributor.authorFuchs, Beth B.
dc.contributor.authorMylonakis, Eleftherios
dc.contributor.authorRosa, Carlos A.
dc.contributor.authorSantos, Daniel A.
dc.contributor.authorJohann, Susana
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade CEUMA (UNICEUMA)
dc.contributor.institutionUniv Estadual de São Paulo
dc.contributor.institutionAlpert Medical School and Brown University
dc.date.accessioned2022-04-28T19:26:31Z
dc.date.available2022-04-28T19:26:31Z
dc.date.issued2018-01-01
dc.description.abstractAim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.en
dc.description.affiliationDepartment of Microbiology Institute of Biological Sciences Universidade Federal de Minas Gerais
dc.description.affiliationPostgraduate Program Universidade CEUMA (UNICEUMA)
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Univ Estadual de São Paulo
dc.description.affiliationDepartment of Pharmaceutical Products Faculdade de Farmácia Universidade Federal de Minas Gerais
dc.description.affiliationDivision of Infectious Diseases Rhode Island Hospital Alpert Medical School and Brown University
dc.identifierhttp://dx.doi.org/10.4155/fsoa-2018-0001
dc.identifier.citationFuture Science OA, v. 4, n. 6, 2018.
dc.identifier.doi10.4155/fsoa-2018-0001
dc.identifier.issn2056-5623
dc.identifier.scopus2-s2.0-85054517769
dc.identifier.urihttp://hdl.handle.net/11449/221179
dc.language.isoeng
dc.relation.ispartofFuture Science OA
dc.sourceScopus
dc.subjectantifungal
dc.subjectCandida albicans
dc.subjectCryptococcus spp.
dc.subjectGalleria mellonella
dc.subjectmice
dc.subjectthiazole
dc.subjectvirulence
dc.titleA phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal modelsen
dc.typeArtigo
dspace.entity.typePublication

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