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Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours

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dc.contributor.authorVargas, T. H. M.
dc.contributor.authorPulz, L. H.
dc.contributor.authorBarra, C. N.
dc.contributor.authorKleeb, S. R.
dc.contributor.authorXavier, J. G. [UNESP]
dc.contributor.authorCatao-Dias, J. L.
dc.contributor.authorFukumasu, H.
dc.contributor.authorNishiya, A. T.
dc.contributor.authorStrefezzi, R. F.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Metodista Sao Paulo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Anhembi Morumbi
dc.date.accessioned2018-11-26T15:28:23Z
dc.date.available2018-11-26T15:28:23Z
dc.date.issued2015-11-01
dc.description.abstractCancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Fac Zootecnia & Engn Alimentos, Lab Oncol Comparada & Translac, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Vet & Zootecnia, Sao Paulo, Brazil
dc.description.affiliationUniv Metodista Sao Paulo, Sao Bernardo Do Campo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sao Paulo, Brazil
dc.description.affiliationUniv Anhembi Morumbi, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2010/05094-5
dc.description.sponsorshipIdFAPESP: 2013/13252-8
dc.format.extent251-255
dc.identifierhttp://dx.doi.org/10.1016/j.jcpa.2015.08.010
dc.identifier.citationJournal Of Comparative Pathology. Oxford: Elsevier Sci Ltd, v. 153, n. 4, p. 251-255, 2015.
dc.identifier.doi10.1016/j.jcpa.2015.08.010
dc.identifier.fileWOS000366883300008.pdf
dc.identifier.issn0021-9975
dc.identifier.urihttp://hdl.handle.net/11449/158629
dc.identifier.wosWOS:000366883300008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Comparative Pathology
dc.relation.ispartofsjr0,594
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectcancer stem cell
dc.subjectdog
dc.subjectmast cell tumour
dc.subjectOCT4 protein
dc.titleImmunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumoursen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication

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