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Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila

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dc.contributor.authorSalminen, Tiina S.
dc.contributor.authorOliveira, Marcos T. [UNESP]
dc.contributor.authorCannino, Giuseppe
dc.contributor.authorLillsunde, Paivi
dc.contributor.authorJacobs, Howard T.
dc.contributor.authorKaguni, Laurie S.
dc.contributor.institutionUniv Tampere
dc.contributor.institutionMichigan State Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Helsinki
dc.date.accessioned2018-11-26T17:33:01Z
dc.date.available2018-11-26T17:33:01Z
dc.date.issued2017-05-01
dc.description.abstractWe evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A +T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype. (C) 2017 Elsevier B.V. and Mitochondria Research Society. All rights reserved.en
dc.description.affiliationUniv Tampere, Inst Biosci & Med Technol, FI-331014 Tampere, Finland
dc.description.affiliationMichigan State Univ, Dept Biochem & Mol Biol, Ctr Mitochondrial Sci & Med, E Lansing, MI 48824 USA
dc.description.affiliationUniv Estadual Paulista, Dept Tecnol, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUniv Helsinki, Inst Biotechnol, FI-00014 Helsinki, Finland
dc.description.affiliationUnespUniv Estadual Paulista, Dept Tecnol, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP, Brazil
dc.description.sponsorshipAcademy of Finland
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipMarie Curie International Incoming Fellowship Program
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdNational Institutes of Health: GM45295
dc.description.sponsorshipIdMarie Curie International Incoming Fellowship Program: 328988
dc.description.sponsorshipIdFAPESP: 2014/02253-6
dc.format.extent75-83
dc.identifierhttp://dx.doi.org/10.1016/j.mito.2017.02.001
dc.identifier.citationMitochondrion. Oxford: Elsevier Sci Ltd, v. 34, p. 75-83, 2017.
dc.identifier.doi10.1016/j.mito.2017.02.001
dc.identifier.fileWOS000402023900011.pdf
dc.identifier.issn1567-7249
dc.identifier.urihttp://hdl.handle.net/11449/162831
dc.identifier.wosWOS:000402023900011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMitochondrion
dc.relation.ispartofsjr1,666
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMitochondrial DNA
dc.subjectHaplotype
dc.subjectCybrid
dc.subjectRespiration
dc.subjectSupercomplexes
dc.titleMitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophilaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.departmentTecnologia - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias