Publicação: Stability study and degradation kinetics of ceftazidime in pharmaceutical preparations
| dc.contributor.author | Moreno, Andréia de Haro [UNESP] | |
| dc.contributor.author | Salgado, Hérida Regina Nunes [UNESP] | |
| dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
| dc.date.accessioned | 2016-01-28T16:56:36Z | |
| dc.date.available | 2016-01-28T16:56:36Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Stability study of ceftazidime was realized in order to investigate kinetics of degradation of this drug both in powder for injection and reconstituted sample. Ceftazidime was submitted to conditions of accelerated thermal degradation and photodegradation. Analyses of the degraded samples were performed by microbiological assay and decomposition reactions could be described by zero-order and second-order kinetics. Results obtained confirm the reliability of the microbiological assay for determination of ceftazidime by the presence of its degradation products. The present study revealed thermal and photo lability of the drug, especially as reconstituted sample, and protection is recommended during storage and handling. | en |
| dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Farmacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jaú, km1, Campus, CEP 14801-902, SP, Brasil | |
| dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Farmacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jaú, km1, Campus, CEP 14801-902, SP, Brasil | |
| dc.description.sponsorship | Fundação para o Desenvolvimento da UNESP (FUNDUNESP) | |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.format.extent | 1-5 | |
| dc.identifier | http://dx.doi.org/10.5923/j.aac.20120201.01 | |
| dc.identifier.citation | Advances in Analytical Chemistry, v. 2, n. 1, p. 1-5, 2012. | |
| dc.identifier.doi | 10.5923/j.aac.20120201.01 | |
| dc.identifier.issn | 2163-2847 | |
| dc.identifier.lattes | 9048202968088646 | |
| dc.identifier.lattes | 9881720291571774 | |
| dc.identifier.uri | http://hdl.handle.net/11449/133787 | |
| dc.language.iso | eng | |
| dc.publisher | Scientific & Academic Publishing | |
| dc.relation.ispartof | Advances in Analytical Chemistry | |
| dc.rights.accessRights | Acesso restrito | pt |
| dc.source | Currículo Lattes | |
| dc.subject | Ceftazidime | en |
| dc.subject | Stability studies | en |
| dc.subject | Degradation kinetics | en |
| dc.title | Stability study and degradation kinetics of ceftazidime in pharmaceutical preparations | en |
| dc.type | Artigo | pt |
| dspace.entity.type | Publication | |
| relation.isDepartmentOfPublication | e214da1b-9929-4ae9-b8fd-655e9bfeda4b | |
| relation.isDepartmentOfPublication.latestForDiscovery | e214da1b-9929-4ae9-b8fd-655e9bfeda4b | |
| relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
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| unesp.author.lattes | 9048202968088646 | |
| unesp.author.lattes | 9881720291571774 | |
| unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
| unesp.department | Fármacos e Medicamentos - FCF | pt |