Equivalência métrica do Disease Activity Score (DAS 28) e Juvenile Arthritis Disease Activity Score (JADAS) na artrite idiopática juvenil
Carregando...
Data
2012-07-05
Autores
Capela, Renata Campos [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
A atividade da artrite pode ser avaliada por diferentes instrumentos. Na Artrite Reumatóide (AR) o Disease Activity Score (DAS 28) e na Artrite Idiopática Juvenil (AIJ) o Juvenile Arthritis Disease Activity Score (JADAS) são utilizados na prática. Explorar a equivalência de medidas contínuas de atividade, o DAS 28 e as 3 versões do JADAS, pontuando 71, 27 e 10 articulações, em portadores de AIJ. Análise secundária de um ensaio clinico, testando o abatacepte em AIJ poliarticular, foi conduzida em 8 sujeitos durante 178 visitas, registrando-se a contagem articular, avaliação global pelo médico em escala analógica visual 0-10 (VAS-MD), avaliação global pelos pacientes/pais (VAS- P) e velocidade de hemossedimentação (VHS) normatizada para escala de 0-100. A comparação longitudinal foi por ANOVA ou modelo ajustado Gama. As observações pareadas entre o DAS 28 e JADAS 71, 27 e 10, respectivamente, foram analisadas por regressão linear após conversão logarítmica (ln). Medidas secundárias de desfecho da artrite como a capacidade funcional por meio do questionário “Childhood Health Assessment Questionnaire” (CHAQ), qualidade do sono por meio do Questionário de Hábitos do sono, limitação de atividades, peso, altura e adequação pondero-estatural foram avaliados de forma descritiva durante todas as visitas. As observações longitudinais das medidas primárias e secundárias de desfecho da artrite apresentaram diferença estatística entre a primeira e a segunda visita comparada as demais num total de 30 visitas e período de observação até 5 anos. As observações longitudinais indicaram diferença significante nos parâmetros DAS 28, JADAS 71, 27 e 10, VAS-MD, VAS-P entre as primeiras duas visitas do estudo original quando 5 atingiram a resposta ACR-Pedi 30 com melhora. A regressão linear para ajustamento do DAS 28 e JADAS resultou em fórmulas para conversão: DAS 28=1.263 x l.285 x In...
Arthritis activity may be assessed by different tools. For Rheumatoid Arthritis (RA), Disease Activity Score (DAS 28) and for Juvenile Idiopathic Arthritis (JIA) the Juvenile Arthritis Disease Activity Score (JADAS), are both used in practice. Explore equivalence of continuous measures of disease activity comparing DAS 28 and each of the 3 versions of JADAS based on 10-, 27- and 71- joint count, in patients with JIA. A secondary analysis of a randomized trial testing abatacept in polyarticular JIA was conducted. 178 assessments in 8 subjects were performed including standardized joint count, physician global assessment by Visual Analog Scale 0-10 (VAS-MD), global assessment by patients/parents (VAS-P) and erythrocyte sedimentation rate (ESR) normalized to 0-100 scale. Comparison by visit was done by ANOVA or gamma adjustment model. Paired observations of DAS 28 and JADAS 71-, 27- and 10-, respectively, were analysed by linear regression after logarithmic scale conversion (ln). Secondary outcome measures as functional capacity by CHAQ tool (Childhood Health Assessment Questionnaire), Sleep Habits Questionnaire, activity limitations, weight, length according to normative values were assessed by descriptive measures along all study visits. Longitudinal comparison of primary and secondary outcome measures resulted in significant difference among the first and second visits compared to the others making 30 visits until 5 years of long-term follow up. Longitudinal comparison by visit indicated significant difference in the first two visits of the original trial for the following parameters DAS 28, JADAS 71-, 27- and 10-, VAS-MD, VAS-P, when 5 subject reached ACR-Pedi 30 improvement response. Linear regression for adjustment between DAS 28 and each JADAS version resulted in transforming formulae: DAS 28=1.263 x ln (JADAS 71) - 1.267 (r2=0.81); DAS 28= 1.288 x ln (JADAS 27) – 1.297 (r2=0.80) e DAS 28= 1.285 x In ...
Arthritis activity may be assessed by different tools. For Rheumatoid Arthritis (RA), Disease Activity Score (DAS 28) and for Juvenile Idiopathic Arthritis (JIA) the Juvenile Arthritis Disease Activity Score (JADAS), are both used in practice. Explore equivalence of continuous measures of disease activity comparing DAS 28 and each of the 3 versions of JADAS based on 10-, 27- and 71- joint count, in patients with JIA. A secondary analysis of a randomized trial testing abatacept in polyarticular JIA was conducted. 178 assessments in 8 subjects were performed including standardized joint count, physician global assessment by Visual Analog Scale 0-10 (VAS-MD), global assessment by patients/parents (VAS-P) and erythrocyte sedimentation rate (ESR) normalized to 0-100 scale. Comparison by visit was done by ANOVA or gamma adjustment model. Paired observations of DAS 28 and JADAS 71-, 27- and 10-, respectively, were analysed by linear regression after logarithmic scale conversion (ln). Secondary outcome measures as functional capacity by CHAQ tool (Childhood Health Assessment Questionnaire), Sleep Habits Questionnaire, activity limitations, weight, length according to normative values were assessed by descriptive measures along all study visits. Longitudinal comparison of primary and secondary outcome measures resulted in significant difference among the first and second visits compared to the others making 30 visits until 5 years of long-term follow up. Longitudinal comparison by visit indicated significant difference in the first two visits of the original trial for the following parameters DAS 28, JADAS 71-, 27- and 10-, VAS-MD, VAS-P, when 5 subject reached ACR-Pedi 30 improvement response. Linear regression for adjustment between DAS 28 and each JADAS version resulted in transforming formulae: DAS 28=1.263 x ln (JADAS 71) - 1.267 (r2=0.81); DAS 28= 1.288 x ln (JADAS 27) – 1.297 (r2=0.80) e DAS 28= 1.285 x In ...
Descrição
Palavras-chave
Artrite idiopática juvenil, Articulações - Doenças, Artrite reumatoide, Rheumatoid arthritis in children
Como citar
CAPELA, Renata Campos. Equivalência métrica do Disease Activity Score (DAS 28) e Juvenile Arthritis Disease Activity Score (JADAS) na artrite idiopática juvenil. 2012. 55 f. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, 2012.