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dc.contributor.authorRossi, Denise M [UNESP]
dc.contributor.authorValenti, Vitor Engrácia [UNESP]
dc.contributor.authorNavega, Marcelo Tavella [UNESP]
dc.date.accessioned2014-05-20T13:31:10Z
dc.date.available2014-05-20T13:31:10Z
dc.date.issued2011-01-01
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322011000900019
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 66, n. 9, p. 1615-1619, 2011.
dc.identifier.issn1807-5932
dc.identifier.urihttp://hdl.handle.net/11449/10620
dc.description.abstractOBJECTIVES: We investigated the effects of chronic (eight weeks) low-to moderate-intensity swimming training on thermal pain sensitivity in streptozotocin-induced diabetic female rats. METHODS: Female Wistar rats (n = 51) were divided into the following groups: trained streptozotocin-induced diabetic rats [hyperglycemic trained (HT)], sedentary streptozotocin-induced diabetic rats [hyperglycemic sedentary (HS)], normoglycemic trained rats (NT) and normoglycemic sedentary rats (NS). Diabetes was induced by a single injection of streptozotocin (50 mg/kg, i.p.). One day after the last exercise protocol (60 min/day, five days/week for eight weeks) in the trained groups or after water stress exposure (ten min/twice a week) in the sedentary groups, the rats were subjected to a hot plate test. RESULTS: After eight weeks of swimming training, streptozotocin-induced diabetic rats presented a significantly lower body mass (trained: 219.5±29 g, sedentary: 217.8±23 g) compared with the normoglycemic groups (trained: 271±24 g, sedentary: 275.7±32 g). Interestingly, we did not find differences in blood glucose levels (mg/dl) between the trained and sedentary groups of the hyperglycemic or normoglycemic rats (HT: 360.2±6.6, HS: 391.7±6.7, NT: 83.8±14.0, NS: 77.5±10.1). In the hot plate test, the rats from the HT group presented a significantly lower latency than the other rats (HT: 11.7±7.38 s, HS: 7.02±7.38 s, NT: 21.21±7.64 s, NS: 22.82±7.82 s). CONCLUSION: Low-to-moderate swimming training for a long duration reduces thermal hyperalgesia during a hot plate test in streptozotocin-induced diabetic female rats.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1615-1619
dc.language.isoeng
dc.publisherUniversidade de São Paulo (USP), Faculdade de Medicina
dc.relation.ispartofClinics
dc.sourceSciELO
dc.subjectDiabetes mellitusen
dc.subjectDiabetic neuropathyen
dc.subjectPain sensitivityen
dc.subjectPhysical exerciseen
dc.subjectSwimming trainingen
dc.subjectHot plate testen
dc.titleExercise training attenuates acute hyperalgesia in streptozotocin-induced diabetic female ratsen
dc.typeArtigo
dcterms.rightsHolderHospital das Clínicas, Universidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUNESP Faculdade de Filosofia e Ciência Departamento de Educação Especial
dc.description.affiliationUniversidade São Paulo Faculdade de Medicina Departamento de Patologia
dc.description.affiliationUnespUNESP Faculdade de Filosofia e Ciência Departamento de Educação Especial
dc.identifier.doi10.1590/S1807-59322011000900019
dc.identifier.scieloS1807-59322011000900019
dc.identifier.wosWOS:000297498400019
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt
dc.identifier.fileS1807-59322011000900019.pdf
dc.identifier.lattes1153464448003029
unesp.author.lattes1153464448003029
unesp.author.orcid0000-0003-0037-3387[1]
unesp.author.orcid0000-0001-7477-3805[2]
dc.relation.ispartofjcr1.245
dc.relation.ispartofsjr0,536
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