Influência do uso de drogas ilícitas na análise seminal e hormonal
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Data
2008-08-15
Autores
Daroz, Gisela Alessandra [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
O objetivo do presente trabalho foi o de avaliar parâmetros seminais e hormonais de homens usuários de drogas ilícitas e compará-los a indivíduos comprovadamente férteis, não usuários destas drogas. No período de outubro de 2006 a dezembro de 2007, 20 homens usuários de drogas ilícitas (maconha e/ou cocaína e/ou crack) e 20 indivíduos férteis não usuários destas drogas foram comparados por meio de análises seminais de acordo com critérios da Organização Mundial de Saúde (1999), e morfologia de Kruger (1986). Foram realizadas dosagens de estradiol, hormônio folículo estimulante, hormônio luteinizante, prolactina, globulina carreadora dos hormônios sexuais (SHBG) e testosterona total por quimioluminescência e calculados os valores do índice androgênico livre (IAL). Os testes t de Student e Mann-Whitney foram utilizados na análise estatística (p<0,05). A média da idade dos usuários de drogas ilícitas foi semelhante ao grupo controle (29 ± 7,78 versus 30 ± 6,2 anos) (p>0,05). A mediana do tempo de uso da drogas foi de 11 anos variando de um a 24 anos. Os usuários de drogas ilícitas comparados aos indivíduos férteis apresentaram uma redução significativa (p<0,05) na concentração/ml: 34,35 ± 29,36 x 106 versus 115,57 ± 90,35 x 106 espermatozóides/ml, na motilidade A+B: 44,85 ± 21,65% versus 64,20 ± 19,30%, na morfologia da OMS: 11,75 ± 8,22% versus 23,10 ± 11,91%, na morfologia de Kruger: 5,30 ± 3,67% versus 9,1 ± 5,88% e um aumento de espermatozóides imóveis: 44,15 ± 21,73% versus 23,35 ± 18,32%. Entre os usuários e não usuários de drogas ilícitas verificamos que houve uma redução significativa no IAL: 77,99 ± 28,21 versus 98,64 ± 32,11; e aumento nos valores de testosterona total: 694,95 ± 181,83 versus 546,15 ± 145,00 ng/dl e SHBG: 32,29 ± 6,16 versus 22,89 ± 14,76 nmol/l. Nos demais parâmetros hormonais...
The objective of this study was to evaluate the seminal and hormonal parameters of male users of illicit drugs and compare them to another group, proved fertile and nonusers of those drugs. From October, 2006 to December, 2007, 20 male users of illicit drugs (cannabis and/or cocaine and/or crack) and 20 fertile men nonusers of those drugs were compared using seminal analysis, according to the World Health Organization (WHO) standards (1999) and the Kruger morphology (1986). The doses of estradiol, luteinizing hormone, prolactin, sex hormone-binding globulin (SHBG) and total testosterone were measured by quimioluminescence and the free androgen index (FAI) levels were calculated. The Student’s t-test and Mann Whitney were used in the statistics analysis (p<0.05). The average age of illicit drugs users was similar to the control group [29 ± 7.78 versus 30 ± 6.2 years old (p<0.05)]. The time of drug utilization ranged from 11 to 24 years (median value). The illicit drug users compared to the nonusers showed a significant decrease (p<0.05) in concentration/ml: 34.35 ± 29.36 versus 115.57 ± 90.35 x 106 spermatozoids/ml, motility A+B: 44.85 ± 21.65 versus 64.20 ± 19.30%, WHO morphology: 11.75 ± 8.22 versus 23.10 ± 11.91%, Kruger’s morphology: 5.30 ± 3.367 versus 9.1 ± 5.88% and an increase in mobile spermatozoids: 44.14 ± 21.73% versus 23.32 ± 18.32%. In both groups it was possible to verify a significant reduction of the FAI: 77.99 ± 28.21 versus 98.64 ± 32.11 and an increase in total testosterone values: 694.95 ± 181.83 versus 546.15 ± 145.00 ng/dl and SHBG: 32.29 ± 6.16 versus 22.89 ± 14.76nmol/l. Significant statistic differences were not observed in further hormonal parameters such as LH, folliclestimulating hormone (FSH), prolactin and estradiol in both groups. The study shows that the use of illicit drugs (cannabis and/or cocaine and/or crack) ...(Complete abstract click electronic access below)
The objective of this study was to evaluate the seminal and hormonal parameters of male users of illicit drugs and compare them to another group, proved fertile and nonusers of those drugs. From October, 2006 to December, 2007, 20 male users of illicit drugs (cannabis and/or cocaine and/or crack) and 20 fertile men nonusers of those drugs were compared using seminal analysis, according to the World Health Organization (WHO) standards (1999) and the Kruger morphology (1986). The doses of estradiol, luteinizing hormone, prolactin, sex hormone-binding globulin (SHBG) and total testosterone were measured by quimioluminescence and the free androgen index (FAI) levels were calculated. The Student’s t-test and Mann Whitney were used in the statistics analysis (p<0.05). The average age of illicit drugs users was similar to the control group [29 ± 7.78 versus 30 ± 6.2 years old (p<0.05)]. The time of drug utilization ranged from 11 to 24 years (median value). The illicit drug users compared to the nonusers showed a significant decrease (p<0.05) in concentration/ml: 34.35 ± 29.36 versus 115.57 ± 90.35 x 106 spermatozoids/ml, motility A+B: 44.85 ± 21.65 versus 64.20 ± 19.30%, WHO morphology: 11.75 ± 8.22 versus 23.10 ± 11.91%, Kruger’s morphology: 5.30 ± 3.367 versus 9.1 ± 5.88% and an increase in mobile spermatozoids: 44.14 ± 21.73% versus 23.32 ± 18.32%. In both groups it was possible to verify a significant reduction of the FAI: 77.99 ± 28.21 versus 98.64 ± 32.11 and an increase in total testosterone values: 694.95 ± 181.83 versus 546.15 ± 145.00 ng/dl and SHBG: 32.29 ± 6.16 versus 22.89 ± 14.76nmol/l. Significant statistic differences were not observed in further hormonal parameters such as LH, folliclestimulating hormone (FSH), prolactin and estradiol in both groups. The study shows that the use of illicit drugs (cannabis and/or cocaine and/or crack) ...(Complete abstract click electronic access below)
Descrição
Palavras-chave
Reprodução humana - Efeito das drogas, Semen, Fertilidade masculina, Hormônios, Hormones
Como citar
DAROZ, Gisela Alessandra. Influência do uso de drogas ilícitas na análise seminal e hormonal. 2008. 67 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2008.