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dc.contributor.authorCarelli, G.
dc.contributor.authorMaffei, Francisco Humberto de Abreu [UNESP]
dc.contributor.authorMattar, L.
dc.contributor.authorFerrari, I. C.
dc.contributor.authorThomazini-Santos, I. A.
dc.contributor.authorde Carvalho, L. R.
dc.date.accessioned2014-05-20T13:32:19Z
dc.date.available2014-05-20T13:32:19Z
dc.date.issued2005-01-01
dc.identifierhttp://dx.doi.org/10.1159/000093105
dc.identifier.citationPathophysiology of Haemostasis and Thrombosis. Basel: Karger, v. 34, n. 6, p. 263-268, 2005.
dc.identifier.issn1424-8832
dc.identifier.urihttp://hdl.handle.net/11449/11035
dc.description.abstractSynergism between low-molecular-weight heparin and low doses of unfractionated heparin (UH) enhancing anti-factor Xa activity and the release of tissue factor pathway inhibitor was observed. The aim of this study was to verify whether this association is effective in preventing experimental venous thrombosis. Seventy rats were allocated into 7 groups: the control group treated with distilled water, the H-350 group treated with UH 350 IU/kg, the E-2 group treated with enoxaparin 2 mg/kg, the H-175 group treated with UH 175 IU/kg, the E-1 group treated with enoxaparin 1 mg/kg, the H-175 + E-1 group treated with UH 175 IU/kg plus enoxaparin 1 mg/kg, and the H-100 + E-0.5 group treated with UH 100 IU/kg plus enoxaparin 0.5 mg/kg. Forty minutes after subcutaneous injection, thrombosis was induced in vena cava. Three hours later, if present, thrombi were withdrawn and weighed. Bleeding time, activated partial thromboplastin time, thrombin time (TT), and anti-factor Xa were measured at the beginning and end of the experiment. Fortyeight other animals were treated, but without inducing thrombus, and tests were performed 40 min after injection. Thrombus developed in 90.9% of control animals, 20% of the H-350 group, 22.2% of the E-2 group, 10% of the H-175 + E-1 group, and 30% of the H-100 + E-0.5 group; there was a difference between group C and the other groups. Only in the H-350 and H-175 + E-1 groups were TT and activated partial thromboplastin time prolonged in relation to control at the end of the experiment. Forty minutes after injection, TT was prolonged in the H-350 and H-175 + E-1 groups. In conclusion, combinations of low doses of low-molecular-weight heparin and low doses of UH were as effective as high doses of each one used alone in preventing thrombus development in rat vena cava. Copyright (c) 2005 S. Karger AG, Basel.en
dc.format.extent263-268
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofPathophysiology of Haemostasis and Thrombosis
dc.sourceWeb of Science
dc.subjectlow-molecular-weight heparinpt
dc.subjectexperimental thrombosispt
dc.subjectrat vena cavapt
dc.titleCombinations of low doses of unfractionated heparin and of low-molecular-weight heparin prevent experimental venous thrombosisen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
dcterms.rightsHolderKarger
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Cirurgia & Ortopedia, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Cirurgia & Ortopedia, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Botucatu, SP, Brazil
dc.identifier.doi10.1159/000093105
dc.identifier.wosWOS:000238425300003
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.author.orcid0000-0003-0575-2263[6]
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