Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country

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Data

2013-01-11

Autores

Velloso, E.D.R.P.
Chauffaille, M.L.
Peliçario, L.M.
Tanizawa, R.S.S.
Toledo, S.R.C.
Gaiolla, Rafael Dezen [UNESP]
Lopes, L.F.

Título da Revista

ISSN da Revista

Título de Volume

Editor

Associação Brasileira de Divulgação Científica (ABRADIC)

Resumo

Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.

Descrição

Palavras-chave

Childhood myelodysplastic syndromes, Juvenile myelomonocytic leukemia, Cytogenetics, Karyotype, Diagnosis

Como citar

Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 46, n. 1, p. 85-90, 2013.