Timoma em cão. Relato de caso
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Data
2000-01-01
Autores
Bandarra, Ênio Pedone [UNESP]
Sequeira, Julio Lopes [UNESP]
MOURA, Veridiana Maria Brianezi Dignani de [UNESP]
Ferreira, Helena [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade de São Paulo (USP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ)
Resumo
Uma cadela, Dachshund, quatro anos, foi encaminhada ao H.V. da FMVZ-UNESP-Botucatu-SP com histórico de prostração, emagrecimento progressivo, anorexia, cansaço e tosse seca. Ao exame clínico observou-se apatia, secreção nasal serosa bilateral e dispnéia intensa. Radiografia torácica demonstrou efusão pleural, edema pulmonar acentuado, desvio dorsal da traquéia e possível massa mediastinal. A ultra-sonografia, após drenagem torácica, confirmou a presença de massa mediastinal, sendo classificada como neoplasia maligna de origem epitelial pela citologia aspirativa por agulha fina. O animal veio a óbito logo após o diagnóstico de neoplasia. À necropsia constatou-se massa mediastinal encapsulada, consistência macia e superfície de corte com coloração branco-acinzentada e áreas necrótico-hemorrágicas, localizada na região ântero-ventral do tórax. O exame histopatológico demonstrou células epiteliais neoplásicas, células linfóides (timócitos) com morfologia normal, vasos sangüíneos de pequeno e médio calibre, formações císticas com conteúdo eosinofílico e corpúsculos de Hassall. A imunohistoquímica apresentou positividade para citoqueratina AE1/AE3 e UCHL, confirmando o diagnóstico de timoma.
A four years old Dachshund female dog was guided to the Veterinary Hospital of FMVZ-UNESP-Botucatu-SP with history of prostration, progressive weigh loss, anorexia, fatigue and drought coughs. Apathy, serous bilateral nasal discharge, intense dyspneia and lung edema were observed in the clinical exam. Thoracic X-ray showed pleural effusion and dorsal deviation of trachea and the presence of a mediastinal mass. The ultrasonography, after thoracic drainage and fine needle aspiration cytology, confirmed the presence of mediastinal mass classified as malignant neoplasm of epithelial origin. The animal died soon after the exams due to its bad clinical conditions. At necropsy mediastinal mass was located in the antero-ventral area of the thorax. It was encapsulated, with soft consistency and gray coloration with hemorragic and necrotic areas in the cut surface. The histopathology demonstrated neoplastic epithelial cells, lymphoid cells (thymocytes) with normal morphology, blood vessels of small and medium caliber, cystic formations with eosinophilic contents and Hassall corpuscles. The immunohistochemistry reaction was positive for cytokeratin AE1/AE3 and UCHL, confirming the thymoma diagnosis.
A four years old Dachshund female dog was guided to the Veterinary Hospital of FMVZ-UNESP-Botucatu-SP with history of prostration, progressive weigh loss, anorexia, fatigue and drought coughs. Apathy, serous bilateral nasal discharge, intense dyspneia and lung edema were observed in the clinical exam. Thoracic X-ray showed pleural effusion and dorsal deviation of trachea and the presence of a mediastinal mass. The ultrasonography, after thoracic drainage and fine needle aspiration cytology, confirmed the presence of mediastinal mass classified as malignant neoplasm of epithelial origin. The animal died soon after the exams due to its bad clinical conditions. At necropsy mediastinal mass was located in the antero-ventral area of the thorax. It was encapsulated, with soft consistency and gray coloration with hemorragic and necrotic areas in the cut surface. The histopathology demonstrated neoplastic epithelial cells, lymphoid cells (thymocytes) with normal morphology, blood vessels of small and medium caliber, cystic formations with eosinophilic contents and Hassall corpuscles. The immunohistochemistry reaction was positive for cytokeratin AE1/AE3 and UCHL, confirming the thymoma diagnosis.
Descrição
Palavras-chave
Cão, Timoma, Imunohistoquímica, Queratina, Dogs, Thymoma, Immunohistochemistry, Keratin
Como citar
Brazilian Journal of Veterinary Research and Animal Science. Faculdade de Medicina Veterinária e Zootecnia / Universidade de São Paulo, v. 37, n. 5, p. 00-00, 2000.