A Genome-Wide Association Study for Morphometric Traits in Quarter Horse
Nenhuma Miniatura disponível
Data
2014-08-01
Autores
Meira, Camila Tângari [UNESP]
Farah, Michel Marques [UNESP]
Fortes, Marina R. S.
Moore, Stephen S.
Pereira, Guilherme L. [UNESP]
Silva, Josineudson Augusto II Vasconcelos [UNESP]
Mota, Marcilio Dias S. da [UNESP]
Curi, Rogerio Abdallah [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
A genome-wide association study for morphometric traits was conducted in 184 Quarter Horses, 120 from a racing population, and 64 from a cutting population, which were genotyped using the Illumina EquineSNP50 chip. Association analysis was performed with 42,058 single-nucleotide polymorphisms (SNPs) (after quality control) using Qxpak5 software. The following traits were measured: weight (W), rump length (RL), and body length (BL). These morphometric traits are important for the best performance in race and cutting events. For weight, three SNPs associated (P < .0001) were found on chromosomes (Equus caballus autosomes [ECA]) 2 and 3. For rump length, eight SNPs associated (P < .0001) were found on ECA 2, 3, 6, 7, 9, 21, and 26. On ECA 3 and ECA 8, two SNPs were associated (P < .0001) with body length. So, a total of 13 important chromosomal regions were identified with Q values of 0.53 (SNPs for W), 0.40 (SNPs for RL), and 0.99 (SNPs for BL). Positional and functional candidate genes emerging from this study were WWOX and AAVPR1A. Further studies are required to confirm these associations in other populations. (c) 2014 Elsevier Inc. All rights reserved.
Descrição
Palavras-chave
Equus caballus, Genetics, Quantitative trait, Single-nucleotide polymorphism
Como citar
Journal Of Equine Veterinary Science. New York: Elsevier Science Inc, v. 34, n. 8, p. 1028-1031, 2014.