Associações anestésicas baseadas em fármacos dissociativos reduzem a pressão intraocular (PIO) em coelhos
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Data
2014-01-01
Autores
Mattos-Junior, Ewaldo de
Cunha, Olicies da
Moraes Barros, Luis Felipe
Hamad Minervino, Antonio Humberto
Nishimura, Lilian Toshiko
Dias, Luis Gustavo Gosuen Gonçalves [UNESP]
Gaido Cortopassi, Silvia Renata
Título da Revista
ISSN da Revista
Título de Volume
Editor
Univ Estadual Londrina
Resumo
The aim of this study was evaluate the effects of three anesthetic combinations, ketamine-midazolam, ketamine-xylazine and tiletamine-zolazepam, on IOP in rabbits. In a experimental, blind, randomized, crossover study, six rabbits were anesthetized with each of 3 treatments in random order. Groups KM (ketamine, 30 mg/kg + midazolam, 1 mg/kg); KX (ketamine, 30 mg/kg + xylazine, 3 mg/kg); and TZ (tiletamine + zolazepam, 20 mg/kg). The drugs were mixed in the same syringe injected intramuscularly (IM) into the quadriceps muscle. IOP was measured before drug administration (baseline) and at 5-minute intervals for 30 minutes. The data were analyzed by a 2-way repeated measures ANOVA followed by Bonferroni test. All groups had significant decreases in IOP compared to baseline (p < 0.001). There was no difference between groups at any of the time points assessed (p > 0.05). Administration of either ketamine-midazolam, ketamine-xylazine, or tiletamine-zolazepam similarly decrease IOP in rabbits within 30 minutes of injection.
Descrição
Palavras-chave
Ketamine, midazolam, Oryctolagus cuniculus, tiletamine, xylazine, zolazepam
Como citar
Semina-ciencias Agrarias. Londrina: Univ Estadual Londrina, v. 35, n. 2, p. 905-909, 2014.