Morphology of ileal and jejunal pouches used as rectal substitutes
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Data
2003-03-01
Autores
Teixeira, Fabio V.
Daud, Danilo
Eleuterio, Maria L.
Silva, Maeli D. P. [UNESP]
Kelly, Keith A.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Lippincott Williams & Wilkins
Resumo
PURPOSE: Our aim was to determine whether the mucosa of a canine jejunal pouch used as a rectal substitute after proctocolectomy retains its morphologic features better than the mucosa of a canine ileal pouch so used. METHODS: Among ten dogs that underwent proctocolectomy, five had a jejunal pouch-distal rectal anastomosis and five an ileal pouch-distal rectal anastomosis. After six months, the animals were killed, the intestinal pouches and portions of unaltered distal ileum were removed, and a blinded, mucosal morphometric analysis was performed. RESULTS: The mucosa of the jejunal pouches had an overall thickness (mean ± standard deviation, anterior and posterior walls, 1,300 ± 140 μm), villous height (286 ± 46 μm), and crypt depth (790 ± 77 μm) greater than that of the ileal pouches (920 ± 170, 208 ± 47, and 530 ± 130 μm, respectively; P < 0.05). Moreover, the mucosal thickness of the jejunal pouches was similar to that of the distal ileum proximal to the pouch (1,200 ± 200 μm; P > 0.05), whereas the mucosal thickness of the ileal pouch was thinner (P < 0.05). CONCLUSIONS: The jejunal mucosa retains its major morphometric features when the jejunum is used as a rectal substitute after proctocolectomy. In contrast, the ileal mucosa atrophies when the ileum is so used.
Descrição
Palavras-chave
Ileal pouch-anal canal anastomosis, Jejunal pouch-anal canal anastomosis, Proctocolectomy, Animal cell, Animal experiment, Animal tissue, Controlled study, Dog, Female, Ileoanal anastomosis, Ileum pouch, Intestine crypt, Intestine metaplasia, Intestine mucosa, Intestine villus, Jejunum, Jejunum pouch, Morphometrics, Nonhuman, Proctocolectomy, Prosthesis, Rectum prosthesis, Animals, Colonic Pouches, Dogs, Female, Intestinal Mucosa, Models, Animal, Proctocolectomy, Restorative
Como citar
Diseases of the Colon and Rectum, v. 46, n. 3, p. 373-376, 2003.