Participation of α2 -adrenoceptors in sodium appetite inhibition during sickness behaviour following administration of lipopolysaccharide
Nenhuma Miniatura disponível
Data
2015
Autores
De Luca Junior, Laurival Antonio [UNESP]
Almeida, Roberto Lopes de
David, Richard Boarato [UNESP]
Paula, Patricia Maria de [UNESP]
Andrade, Carina Aparecida Fabrício de [UNESP]
Menani, José Vanderlei [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Sickness behaviour, a syndrome characterized by a general reduction in animal activity, is part of the active-phase response to fight infection. Lipopolysaccharide (LPS), an effective endotoxin to model sickness behaviour, reduces thirst and sodium excretion, and increases neurohypophysial secretion. Here we review the effects of LPS on thirst and sodium appetite. Altered renal function and hydromineral fluid intake in response to LPS occur in the context of behavioural reorganization, which manifests itself as part of the syndrome. Recent data show that, in addition to its classical effect on thirst, non-septic doses of LPS injected intraperitoneally produce a preferential inhibition of intracellular thirst versus extracellular thirst. Moreover, LPS also reduced hypertonic NaCl intake in sodium-depleted rats that entered a sodium appetite test. Antagonism of α2 -adrenoceptors abolished the effect of LPS on sodium appetite. LPS and cytokine transduction potentially recruit brain noradrenaline and α2 -adrenoceptors to control sodium appetite and sickness behaviour.
Descrição
Palavras-chave
Como citar
The Journal Of Physiology, 2015.