Neuroglia and their roles in central respiratory control; an overview
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Data
2015
Autores
Funk, Gregory D.
Rajani, Vishaal
Alvares, Tucaauê S.
Revill, Ann L.
Zhang, Yong
Chu, Nathan Y.
Biancardi, Vivian [UNESP]
Linhares-Taxini, Camila [UNESP]
Katzell, Alexis
Reklow, Robert
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B. V.
Resumo
While once viewed as mere housekeepers, providing structural and metabolic support for neurons, it is now clear that neuroglia do much more. Phylogenetically, they have undergone enormous proliferation and diversification as central nervous systems grew in their complexity. In addition, they: i) are morphologically and functionally diverse; ii) play numerous, vital roles in maintaining CNS homeostasis; iii) are key players in brain development and responses to injury; and, iv) via gliotransmission, are likely participants in information processing. In this review, we discuss the diverse roles of neuroglia in maintaining homeostasis in the CNS, their evolutionary origins, the different types of neuroglia and their functional significance for respiratory control, and finally consider evidence that they contribute to the processing of chemosensory information in the respiratory network and the homeostatic control of blood gases.
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Palavras-chave
Central chemosensitivity, Gliotransmission, Homeostasis, Hypoxic ventilatory response, Neuroglia, Neuromodulation, Prebötzinger complex, Purinergic signaling, Retrotrapezoid nucleus
Como citar
Comparative Biochemistry and Physiology. Part A, Molecular and Integrative Physiology, v. 186, p. 83-95, 2015.