Increased DNA damage is related to maternal blood glucose levels in the offspring of women with diabetes and mild gestational hyperglycemia
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Data
2015-09-02
Autores
Gelaleti, Rafael Bottaro [UNESP]
Damasceno, Débora C. [UNESP]
Santos, Daniele P.
Calderon, Iracema M P [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
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Resumo
This study aimed at correlating maternal blood glucose levels with DNA damage levels in the offspring of women with diabetes or mild gestational hyperglycemia (MGH). Based on oral glucose tolerance test results and glycemic profiles, 56 pregnant women were allocated into 3 groups: nondiabetes, MGH, and diabetes. The offspring of these women (56 infants) were also evaluated. Maternal peripheral blood and umbilical cord blood samples were collected and processed for biochemical and DNA damage analysis by the comet assay. A positive correlation between maternal blood glucose mean and increased offspring DNA damage levels was observed. Hyperglycemia played a role in offspring DNA damage, but other diabetes-induced complications were also involved. Increased maternal blood glucose levels can lead to increased offspring DNA damage levels. Therefore, the monitoring, control, and treatment of pregnant women with diabetes and MGH are highly important to ensure a risk-free pregnancy and healthy infants.
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Dna damage, Diabetes, Mild gestational hyperglycemia, Newborns, Pregnant women
Como citar
Reproductive Sciences (thousand Oaks, Calif.), p. 771–775, 2015.