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dc.contributor.authorAriza, Deborah
dc.contributor.authorLopes, Fernanda Novi Cortegoso
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorMartins-Pinge, Marli Cardoso
dc.date.accessioned2015-12-07T15:39:38Z
dc.date.available2015-12-07T15:39:38Z
dc.date.issued2015-10-21
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2015.09.024
dc.identifier.citationNeuroscience Letters, v. 607, p. 77-82, 2015.
dc.identifier.issn1872-7972
dc.identifier.urihttp://hdl.handle.net/11449/131656
dc.description.abstractParkinson's disease (PD) is mainly characterized by motor signals. However, non-motor signals also affect and decrease the quality of life of PD patients. Among these non-motor signs are cardiovascular disorders as orthostatic hypotension, postprandial hypotension and cardiac arrhythmias, which may be due to the involvement of both central nervous system and peripheral autonomic nervous system. In the present study we investigated the cardiovascular function, evaluating cardiovascular reflexes (chemoreflex and baroreflex), in an animal model of Parkinsonism induced by bilateral infusion of the toxin 6-hydroxydopamine (6-OHDA), in the substantia nigra pars compacta (SNpc). The results showed that the animals induced to Parkinsonism had lower arterial pressure (AP) and heart rate HR) compared to control animals. We showed that after activation of the baroreceptors by phenylephrine (Phe) and sodium nitroprusside (SNP), the baroreflex sensitivity index was not changed between the groups. However, there was a greater increase in the AP when stimulated with Phe and greater tachycardia when stimulated with SNP in 6-OHDA animals. After activation of the peripheral chemoreceptors through KCN injection (cytotoxic hypoxia), there was a higher increase in pressor and bradycardic response in injured animals with bilateral 6-OHDA. These changes in the cardiovascular reflexes may be important adjustments mechanisms to maintain the cerebral blood flow in those animals, and may be a result of denervation supersensitivity to catecholamines in autonomic targets.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent77-82
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofNeuroscience Letters
dc.sourcePubMed
dc.subjectArterial pressureen
dc.subjectDysautonomiaen
dc.subjectHeart rateen
dc.subjectPhenylephrineen
dc.subjectPotassium cyanideen
dc.subjectSodium nitroprussideen
dc.titleChemoreflex and baroreflex alterations in Parkinsonism induced by 6-OHDA in unanesthetized ratsen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil.
dc.description.affiliationSchool of Pharmaceutical Sciences, State University of São Paulo-UNESP, Araraquara, SP, Brazil.
dc.description.affiliationDepartment of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil. Electronic address: martinspinge@uel.br.
dc.description.affiliationUnespSchool of Pharmaceutical Sciences, State University of São Paulo-UNESP, Araraquara, SP, Brazil.
dc.identifier.doi10.1016/j.neulet.2015.09.024
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.lattes1117432571971568
dc.identifier.pubmed26409036
unesp.author.lattes1117432571971568
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