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dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.authorRomeiro, Fernando Gomes [UNESP]
dc.contributor.authorMartinez, Paula Felippe [UNESP]
dc.contributor.authorOliveira Junior, Silvio Assis de [UNESP]
dc.contributor.authorPolegato, Bertha Furlan [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.date.accessioned2016-07-07T12:33:58Z
dc.date.available2016-07-07T12:33:58Z
dc.date.issued2014
dc.identifierhttp://dx.doi.org/10.2147/RRCC.S41513
dc.identifier.citationResearch Reports in Clinical Cardiology, v. 5, p. 319-326, 2014.
dc.identifier.issn1179-8475
dc.identifier.urihttp://hdl.handle.net/11449/140466
dc.description.abstractCachexia and muscle wasting are frequently observed in heart failure patients. Cachexia is a predictor of reduced survival, independent of important parameters such as age, heart failure functional class, and functional capacity. Muscle and fat wasting can also predict adverse outcome during cardiac failure. Only more recently were these conditions defined in International Consensus. Considering that heart failure is an inflammatory disease, cardiac cachexia has been diagnosed by finding a body weight loss .5%, in the absence of other diseases and independent of other criteria. Muscle wasting has been defined as lean appendicular mass corrected for height squared of 2 standard deviations or more below the mean for healthy individuals between 20 years and 30 years old from the same ethnic group. The etiology of heart failure-associated cachexia and muscle wasting is multifactorial, and the underlying physiopathological mechanisms are not completely understood. The most important factors are reduced food intake, gastrointestinal alterations, immunological activation, neurohormonal abnormalities, and an imbalance between anabolic and catabolic processes. Cachexia and muscle wasting have clinical consequences in several organs and systems including the gastrointestinal and erythropoietic systems, and the heart, previously affected by the primary disease. We hope that a better understanding of the mechanisms involved in their physiopathology will allow the development of pharmacological and nonpharmacological therapies to effectively prevent and treat heart failure-induced cachexia and muscle wasting before significant body weight and muscle wasting occurs.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent319-326
dc.language.isoeng
dc.relation.ispartofResearch Reports in Clinical Cardiology
dc.sourceCurrículo Lattes
dc.subjectHeart failureen
dc.subjectPrognosisen
dc.subjectAnorexiaen
dc.subjectInflammatory activationen
dc.subjectCardiac wastingen
dc.titleCardiac cachexia and muscle wasting: definition, physiopathology, and clinical consequencesen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.description.affiliationUniversidade Federal de Mato Grosso do Sul, Faculdade de Fisioterapia
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu
dc.identifier.doi10.2147/RRCC.S41513
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2012/21687-1
dc.description.sponsorshipIdFAPESP: 2012/50512-5
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
dc.identifier.fileISSN1179-8475-2014-05-319-326.pdf
dc.identifier.lattes4463138671998432
dc.identifier.lattes1590971576309420
dc.identifier.lattes1590971576309420
dc.identifier.lattes1590971576309420
unesp.departmentClínica Médicapt
dc.identifier.orcid0000-0001-8980-8839
unesp.author.lattes4463138671998432
unesp.author.lattes1590971576309420
unesp.author.lattes1590971576309420
unesp.author.lattes4563764623232492[5]
unesp.author.orcid0000-0001-8980-8839
unesp.author.orcid0000-0002-2875-9532[5]
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