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dc.contributor.authorAfonso, M.
dc.contributor.authorde Oliveira Bello, V
dc.contributor.authorShibli, J. A.
dc.contributor.authorSposto, M. R.
dc.identifier.citationJournal of Periodontology. Chicago: Amer Acad Periodontology, v. 74, n. 1, p. 51-56, 2003.
dc.description.abstractBackground: the incidence of gingival overgrowth (GO) associated with the use of cyclosporin A (CsA) is controversial. In the present study, we determined the incidence of GO in Brazilian renal transplant patients treated with CsA and the possible associations between periodontal and pharmacological variables.Methods: the test group consisted of 20 renal transplant patients, and the control group included 20 non-transplant patients. Periodontal conditions were evaluated based on the plaque index (PI), gingival index (GI), probing depth (PD), and the rate of gingival overgrowth, together with pharmacological variables (daily CsA dose and duration of treatment).Results: A significant difference in PI (P<0.0001) and PD (P<0.0001) was observed between groups, while GI (P=0.15) did not differ significantly. Using the Pearson correlation coefficient, a significant correlation was observed not only between GI (P<0.001; r=0.8141) and GO, but also for PD (P<0.001; r=0.866) and GO. The other correlations were not statistically significant.Conclusions: We conclude that GO induced by CsA may vary according to the individual sensitivity of each patient and may or may not be correlated with other local factors (periodontal variables).en
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.sourceWeb of Science
dc.subjectclinical evaluation/periodontal diseasespt
dc.subjectcyclosporin A/adverse effectspt
dc.subjectgingival hyperplasia/epidemiologypt
dc.subjectgingival hyperplasia/etiologypt
dc.subjectperiodontal indexpt
dc.subjectrenal transplantation/adverse effectspt
dc.titleCyclosporin A-induced gingival overgrowth in renal transplant patientsen
dcterms.rightsHolderAmer Acad Periodontology
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBase Hosp
dc.contributor.institutionUniv Buffalo
dc.description.affiliationUNESP, Dept Diagnosis & Oral Surg, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationBase Hosp, Kidney Transplant Unit, Brasilia, DF, Brazil
dc.description.affiliationUniv Buffalo, Sch Dent Med, Dept Oral Biol, Buffalo, NY USA
dc.description.affiliationUnespUNESP, Dept Diagnosis & Oral Surg, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt[3]
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